Evidence map›Paper›PMID 38712546›Full record

ArticleActa crystallographica. Section C, Structural chemistry2024

Applying 3D ED/MicroED workflows toward the next frontiers.

Mahira Aragon, Sarah E J Bowman, Chun Hsing Chen, M Jason de la Cruz, Daniel A Decato, Edward T Eng, Kristen M Flatt, Sahil Gulati, Yuchen Li, Charles J Lomba and 6 more

Abstract read
In one paragraph

Article in Acta crystallographica. Section C, Structural chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. An Updated Structure of Oxybutynin Hydrochloride.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. 3D ED/MicroED entering a new era.Acta crystallographica. Section C, Structural chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mahira AragonSimons Electron Microscopy Center, New York Structural Biology Center, 89 Convent Ave, New York, New York 10027, USA.ORCID 0000-0002-0004-6514
Sarah E J BowmanHauptman-Woodward Medical Research Institute, 700 Ellicott St, Buffalo, New York 14203, USA.ORCID 0000-0002-7426-7328
Chun Hsing ChenDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA.ORCID 0000-0003-0150-9557
M Jason de la CruzMemorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.ORCID 0000-0002-8573-5406
Daniel A DecatoChemistry and Biochemistry, University of Montana, 32 Campus Drive, Missoula, Montana 59812, USA.ORCID 0009-0008-0678-4455
Edward T EngSimons Electron Microscopy Center, New York Structural Biology Center, 89 Convent Ave, New York, New York 10027, USA.ORCID 0000-0002-8014-7269
Kristen M FlattMaterials Research Laboratory, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA.ORCID 0000-0003-3571-7821
Sahil GulatiGatan Inc., Pleasanton, CA 94588, USA.ORCID 0000-0002-8255-479X
Yuchen LiDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.ORCID 0000-0002-3876-0879
Charles J LombaDepartment of Physics, Quantitative Biology Institute, Yale University, 260 Whitney Ave., New Haven, Connecticut 06520-8103, USA.ORCID 0000-0002-6574-4276
Brandon MercadoDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, USA.ORCID 0000-0002-1940-3497
Jessalyn MillerSimons Electron Microscopy Center, New York Structural Biology Center, 89 Convent Ave, New York, New York 10027, USA.ORCID 0000-0002-0396-8549
Lukáš PalatinusInstitute of Physics of the CAS/NanED, Na Slovance 1999/2, Prague 192000, Czech Republic.ORCID 0000-0002-8987-8164
William J RiceDepartment of Cell Biology, NYU Grossman School of Medicine, 540 First Ave, New York, New York 10016, USA.ORCID 0000-0002-5187-255X
David WatermanResearch Complex at Harwell, UKRI-STFC Rutherford Appleton Laboratory, Harwell, Didcot, Oxfordshire, OX11 0FA, England, United Kingdom.ORCID 0000-0002-2134-182X
Christina M ZimanyiSimons Electron Microscopy Center, New York Structural Biology Center, 89 Convent Ave, New York, New York 10027, USA.ORCID 0000-0002-6782-507X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP20GM103546 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2012 to 2021
$19.2M
New techniques for detecting and handling nanocrystals for cutting edge structural biology methodsR01GM141273 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BOWMAN, SARAH ELIZABETH JOHNSON · 2022 to 2025
$1.5M
Biotechnology and Biological Sciences Research Council BB/S007040/1EU H2020 ITN project NanED 956099National Institutes of Health, National Institute of General Medical Sciences 5R01GM141273National Institutes of Health, National Institute of General Medical Sciences P30GM103546National Science Foundation 2132227NCI NIH HHS P30 CA008748NIGMS NIH HHS P20 GM103546NIGMS NIH HHS R01 GM141273NIGMS NIH HHS U24 GM129539Simons Foundation SF349247
6 · The paper itself

Abstract

We report on the latest advancements in Microcrystal Electron Diffraction (3D ED/MicroED), as discussed during a symposium at the National Center for CryoEM Access and Training housed at the New York Structural Biology Center. This snapshot describes cutting-edge developments in various facets of the field and identifies potential avenues for continued progress. Key sections discuss instrumentation access, research applications for small molecules and biomacromolecules, data collection hardware and software, data reduction software, and finally reporting and validation. 3D ED/MicroED is still early in its wide adoption by the structural science community with ample opportunities for expansion, growth, and innovation.

Indexed as

Cryoelectron MicroscopySoftwareWorkflow3D EDelectron diffractionmicrocrystal electron diffractionMicroED

Identifiers

PMID38712546
PMCPMC11150879

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.