ArticleBrain communications2024
Systemic inflammation associates with and precedes cord atrophy in progressive multiple sclerosis.
Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Association of Glycemic Status with Disability, Relapse Activity, Inflammatory Markers, and Metabolic Profile in Patients with Multiple Sclerosis.Journal of clinical medicine · 2026Article
- Erythrocyte Fragility in Progressive Multiple Sclerosis.European journal of neurology · 2026Article
- Chronic uropathogenic Escherichia coli infections in adolescence: in vitro analysis of clinical isolates, multidrug resistance, and in vivo hippocampal cognitive impacts.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Chronic low-grade inflammation, genetic susceptibility, and the risk of multiple sclerosis: a prospective cohort study.Frontiers in immunology · 2026Article
- Insights from DCE-MRI: blood-brain barrier permeability in the context of MS relapses and methylprednisolone treatment.Frontiers in neuroscience · 2025Article
- Immunometabolic profiling in menopausal women with multiple sclerosis: the role of adipokines and hormone therapy.BMJ neurology open · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In preclinical models of multiple sclerosis, systemic inflammation has an impact on the compartmentalized inflammatory process within the central nervous system and results in axonal loss. It remains to be shown whether this is the case in humans, specifically whether systemic inflammation contributes to spinal cord or brain atrophy in multiple sclerosis. Hence, an observational longitudinal study was conducted to delineate the relationship between systemic inflammation and atrophy using magnetic resonance imaging: the SIMS (Systemic Inflammation in Multiple Sclerosis) study. Systemic inflammation and progression were assessed in people with progressive multiple sclerosis (
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Registered trials
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