Evidence map›Paper›PMID 38712289›Full record

ArticlebioRxiv : the preprint server for biology2024

Generation of a zebrafish neurofibromatosis model via inducible knockout of

Ayyappa Raja Desingu Rajan, Yuanyun Huang, Jan Stundl, Katelyn Chu, Anushka Irodi, Zihan Yang, Brian E Applegate, Marianne E Bronner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ayyappa Raja Desingu RajanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-0173-0465
Yuanyun HuangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jan StundlDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0002-3740-3378
Katelyn ChuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Anushka IrodiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Zihan YangUniversity of Southern California, Caruso Department of Otolaryngology-Head & Neck Surgery, Los Angeles, CA, USA.
Brian E ApplegateUniversity of Southern California, Caruso Department of Otolaryngology-Head & Neck Surgery, Los Angeles, CA, USA.ORCID 0000-0003-2795-5678
Marianne E BronnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0003-4274-1862

Funding

Progressive acquisition of novel neural crest derivatives along the neural axis during vertebrate evolutionR35NS111564 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Marianne Bronner · 2019 to 2026
$5.0M
NINDS NIH HHS R35 NS111564
6 · The paper itself

Abstract

Neurofibromatosis Type 2 (NF-2) is a dominantly inherited genetic disorder that results from mutations in the tumor suppressor gene, neurofibromin 2 (NF2) gene. Here, we report the generation of a conditional zebrafish model of neurofibromatosis established by an inducible genetic knockout of

Identifiers

PMID38712289
PMCPMC11071375

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.