Evidence map›Paper›PMID 38712277›Full record

ArticlebioRxiv : the preprint server for biology2024

A deoxynucleoside triphosphate triphosphohydrolase promotes cell cycle progression in

Chandler N Hellenbrand, David M Stevenson, Katarzyna A Gromek, Daniel Amador-Noguez, David M Hershey

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Chandler N HellenbrandDepartment of Bacteriology, University of Wisconsin - Madison, Madison, WI 53706, USA.
David M StevensonDepartment of Bacteriology, University of Wisconsin - Madison, Madison, WI 53706, USA.
Katarzyna A GromekDepartment of Bacteriology, University of Wisconsin - Madison, Madison, WI 53706, USA.
Daniel Amador-NoguezDepartment of Bacteriology, University of Wisconsin - Madison, Madison, WI 53706, USA.ORCID 0000-0002-3568-3070
David M HersheyDepartment of Bacteriology, University of Wisconsin - Madison, Madison, WI 53706, USA.ORCID 0000-0001-8745-9524

Funding

Surface adaptation in bacterial cellsR35GM150652 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI David M. Hershey · 2023 to 2026
$1.7M
NIGMS NIH HHS R35 GM150652
6 · The paper itself

Abstract

Intracellular pools of deoxynucleoside triphosphates (dNTPs) are strictly maintained throughout the cell cycle to ensure accurate and efficient DNA replication. DNA synthesis requires an abundance of dNTPs, but elevated dNTP concentrations in nonreplicating cells delay entry into S phase. Enzymes known as deoxyguanosine triphosphate triphosphohydrolases (Dgts) hydrolyze dNTPs into deoxynucleosides and triphosphates, and we propose that Dgts restrict dNTP concentrations to promote the G1 to S phase transition. We characterized a Dgt from the bacterium

Identifiers

PMID38712277
PMCPMC11071499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.