Evidence map›Paper›PMID 38712253›Full record

ArticlebioRxiv : the preprint server for biology2024

Improved mouse models of the small intestine microbiota using region-specific sampling from humans.

Rebecca N Culver, Sean Paul Spencer, Arvie Violette, Evelyn Giselle Lemus Silva, Tadashi Takeuchi, Ceena Nafarzadegan, Steven K Higginbottom, Dari Shalon, Justin Sonnenburg, Kerwyn Casey Huang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rebecca N CulverDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-3963-193X
Sean Paul SpencerDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-7328-5399
Arvie VioletteDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0004-9561-8926
Evelyn Giselle Lemus SilvaDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-0729-8757
Tadashi TakeuchiDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-1693-7490
Ceena NafarzadeganDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0009-0002-1709-2207
Steven K HigginbottomDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-4609-6840
Dari ShalonEnvivo Bio, Inc., San Francisco, CA 94107, USA.ORCID 0000-0003-2646-6215
Justin SonnenburgDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-2299-6817
Kerwyn Casey HuangDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-8043-8138

Funding

A universal pipeline for functional characterization of the human microbiota at a massive scaleRM1GM135102 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BUIE, CULLEN RICHARD, DEUTSCHBAUER, ADAM M · 2020 to 2024
$7.6M
TRAINING GRANT IN ACADEMIC GASTROENTEROLOGYT32DK007056 · NIDDK · STANFORD UNIVERSITY · PI Natalie J. Torok · 1986 to 2026
$6.5M
Molecular Biophysics Training Program at StanfordT32GM136568 · NIGMS · STANFORD UNIVERSITY · PI Zev Bryant, KERWYN C. HUANG · 2021 to 2026
$3.7M
Antimicrobial Resistance and Horizontal Gene Transfer in the Human Gut Microbiome in Response to an AntibioticR01AI147023 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI RELMAN, DAVID A. · 2020 to 2024
$3.5M
Defining Small Intestinal Microbial Landscapes To Improve Therapeutics For Gastrointestinal DiseaseK08DK134856 · NIDDK · STANFORD UNIVERSITY · PI Sean Paul Spencer · 2023 to 2026
$664k
NIAID NIH HHS R01 AI147023NIDDK NIH HHS K08 DK134856NIDDK NIH HHS T32 DK007056NIGMS NIH HHS RM1 GM135102NIGMS NIH HHS T32 GM136568
6 · The paper itself

Abstract

Our understanding of region-specific microbial function within the gut is limited due to reliance on stool. Using a recently developed capsule device, we exploit regional sampling from the human intestines to develop models for interrogating small intestine (SI) microbiota composition and function.

Indexed as

dietEnterococcusgut microbiomeintestinal samplingin vitro communitiesmicrobiota accessible carbohydratespriority effectsregional specificitystrain isolationstrain librarysynthetic communities

Identifiers

PMID38712253
PMCPMC11071525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.