ArticlebioRxiv : the preprint server for biology2024
Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma.
Y Licón-Muñoz, V Avalos, S Subramanian, B Granger, F Martinez, S Varela, D Moore, E Perkins, M Kogan, S Berto and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors.
Y Licón-MuñozThe Brain Tumor Translational Laboratory, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM.ORCID 0000-0002-6034-9058 V AvalosThe Brain Tumor Translational Laboratory, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM.
S SubramanianBioinformatics Core, Department of Neuroscience, Medical University of South Carolina, Charleston, SC.ORCID 0009-0007-2822-9420 B GrangerBioinformatics Core, Department of Neuroscience, Medical University of South Carolina, Charleston, SC.
F MartinezThe Brain Tumor Translational Laboratory, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM.
S VarelaUniversity of New Mexico School of Medicine, Albuquerque, NM.
D MooreBioinformatics Core, Department of Neuroscience, Medical University of South Carolina, Charleston, SC.ORCID 0009-0005-0926-0874 E PerkinsDepartment of Neurosurgery, University of Mississippi Medical Center, Jackson, MS.
M KoganDepartment of Neurosurgery, University of New Mexico Hospital, Albuquerque, NM.
S BertoBioinformatics Core, Department of Neuroscience, Medical University of South Carolina, Charleston, SC.ORCID 0000-0001-9028-9458 S G M PiccirilloThe Brain Tumor Translational Laboratory, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM.ORCID 0000-0003-4109-1992 Funding
WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1MUnfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Samuel Joseph Endicott · 2017 to 2026
$24.9MThe Role of Early Life Stress in Feeding BehaviorsP20GM148302 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jose H Ledo · 2023 to 2026
$11.5MNCI NIH HHS P30 CA118100NIGMS NIH HHS P20 GM121176NIGMS NIH HHS P20 GM148302
6 · The paper itselfAbstract
The sub-ventricular zone (SVZ) is the most well-characterized neurogenic area in the mammalian brain. We previously showed that in 65% of patients with glioblastoma (GBM), the SVZ is a reservoir of cancer stem-like cells that contribute to treatment resistance and emergence of recurrence. Here, we built a single-nucleus RNA-sequencing-based microenvironment landscape of the tumor mass (T_Mass) and the SVZ (T_SVZ) of 15 GBM patients and 2 histologically normal SVZ (N_SVZ) samples as controls. We identified a mesenchymal signature in the T_SVZ of GBM patients: tumor cells from the T_SVZ relied on the
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PMID38712234
PMCPMC11071523
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