Evidence map›Paper›PMID 38712153›Full record

ArticlebioRxiv : the preprint server for biology2024

Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.

Luis E Martinetti, Dawn M Autio, Shane R Crandall

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Luis E MartinettiNeuroscience Program, Michigan State University, East Lansing, MI 48824.
Dawn M AutioDepartment of Physiology, Michigan State University, East Lansing, MI 48824.
Shane R CrandallNeuroscience Program, Michigan State University, East Lansing, MI 48824.ORCID 0000-0003-0611-3981

Funding

Dynamic properties of neural circuits in the forebrainR01NS117636 · NINDS · MICHIGAN STATE UNIVERSITY · PI Shane R Crandall · 2022 to 2026
$1.9M
Dynamic properties of corticothalamic circuitsR00NS096108 · NINDS · MICHIGAN STATE UNIVERSITY · PI CRANDALL, SHANE R · 2018 to 2020
$843k
Motor feedback control of layer six circuitsF31NS124244 · NINDS · MICHIGAN STATE UNIVERSITY · PI MARTINETTI, LUIS ENRIQUE · 2021 to 2023
$101k
NINDS NIH HHS F31 NS124244NINDS NIH HHS R00 NS096108NINDS NIH HHS R01 NS117636
6 · The paper itself

Abstract

Layer 6 corticothalamic (L6 CT) neurons provide massive input to the thalamus, and these feedback connections enable the cortex to influence its own sensory input by modulating thalamic excitability. However, the functional role(s) feedback serves during sensory processing is unclear. One hypothesis is that CT feedback is under the control of extra-sensory signals originating from higher-order cortical areas, yet we know nothing about the mechanisms of such control. It is also unclear whether such regulation is specific to CT neurons with distinct thalamic connectivity. Using mice (either sex) combined with

Identifiers

PMID38712153
PMCPMC11071411

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.