Evidence map›Paper›PMID 38712144›Full record

ArticlebioRxiv : the preprint server for biology2024

PACS-1 variant protein is aberrantly localized in

Dana T Byrd, Ziyuan Christina Han, Christopher A Piggott, Yishi Jin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Dana T ByrdDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093.ORCID 0009-0003-5659-7723
Ziyuan Christina HanDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093.
Christopher A PiggottDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093.
Yishi JinDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, CA 92093.ORCID 0000-0002-9371-9860

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular genetics of axon and synapse development and maintenanceR35NS127314 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yishi Jin · 2022 to 2026
$4.3M
Identifying potential therapeutics using an animal model for PACS1 syndromeR03NS121487 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BYRD, DANA T, JIN, YISHI · 2021 to 2021
$158k
NIH HHS P40 OD010440NINDS NIH HHS R03 NS121487NINDS NIH HHS R35 NS127314
6 · The paper itself

Abstract

PACS (Phosphofurin Acidic Cluster Sorting Protein) proteins are known for their roles in sorting cargo proteins to organelles and can physically interact with WD40 repeat-containing protein WDR37. PACS1, PACS2, and WDR37 variants are associated with multisystemic syndromes and neurodevelopmental disorders characterized by intellectual disability, seizures, developmental delays, craniofacial abnormalities, and autism spectrum disorder. However, the effects of syndromic variants on function

Indexed as

embryonic developmentFurin-binding domainneuronal developmentprotein sortingrare disease mutationssynaptic functionWDR-37

Identifiers

PMID38712144
PMCPMC11071410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.