ArticlebioRxiv : the preprint server for biology2024
Identification of high sugar diet-induced dysregulated metabolic pathways in muscle using tissue-specific metabolic models in
Sun Jin Moon, Yanhui Hu, Monika Dzieciatkowska, Ah-Ram Kim, Po-Lin Chen, John M Asara, Angelo D'Alessandro, Norbert Perrimon
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045.
Po-Lin ChenDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
John M AsaraDivision of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045.ORCID 0000-0002-2258-6490 Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6MTuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MCharacterization of the Insulin to Autophagy Pathway in MusclesR01AR057352 · NIAMS · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2010 to 2026
$8.2MInvestigating metabolic responses to high sugar diets and the onset of diabetic phenotypesR01DK136945 · NIDDK · TRUSTEES OF INDIANA UNIVERSITY · PI Angelo D'Alessandro, NORBERT PERRIMON · 2023 to 2026
$2.4MCANCAN ? CORNELLOT2CA278685 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GONCALVES, MARCUS DASILVA · 2022 to 2023
$657kNCI NIH HHS OT2 CA278685NCI NIH HHS P01 CA120964NCI NIH HHS P30 CA006516NIAMS NIH HHS R01 AR057352NIDDK NIH HHS R01 DK136945
6 · The paper itselfAbstract
Individual tissues perform highly specialized metabolic functions to maintain whole-body homeostasis. Although
Indexed as
13C isotope tracingDrosophilaflux balance analysisGAPDHgenome-scale metabolic modelhigh sugar dietNADH/NAD+Tissue metabolism
Identifiers
PMID38712132
PMCPMC11071505
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