Evidence map›Paper›PMID 38712106›Full record

ArticlebioRxiv : the preprint server for biology2024

ModDotPlot-Rapid and interactive visualization of complex repeats.

Alexander P Sweeten, Michael C Schatz, Adam M Phillippy

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Alexander P SweetenDepartment of Computer Science, Johns Hopkins University, Baltimore, MD 21211, USA.ORCID 0000-0002-5316-2973
Michael C SchatzDepartment of Computer Science, Johns Hopkins University, Baltimore, MD 21211, USA.ORCID 0000-0002-4118-4446
Adam M PhillippyGenome Informatics Section, Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-2983-8934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: A common method for analyzing genomic repeats is to produce a sequence similarity matrix visualized via a dot plot. Innovative approaches such as StainedGlass have improved upon this classic visualization by rendering dot plots as a heatmap of sequence identity, enabling researchers to better visualize multi-megabase tandem repeat arrays within centromeres and other heterochromatic regions of the genome. However, computing the similarity estimates for heatmaps requires high computational overhead and can suffer from decreasing accuracy. Results: In this work we introduce ModDotPlot, an interactive and alignment-free dot plot viewer. By approximating average nucleotide identity via a Availability and Implementation: ModDotPlot is available at https://github.com/marbl/ModDotPlot.

Identifiers

PMID38712106
PMCPMC11071298

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.