Evidence map›Paper›PMID 38712090›Full record

ArticlebioRxiv : the preprint server for biology2024

Human polymerase theta helicase positions DNA microhomologies for double-strand break repair.

Christopher J Zerio, Yonghong Bai, Brian A Sosa-Alvarado, Timothy Guzi, Gabriel C Lander

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Christopher J ZerioDepartment of Integrative Structural and Computational Biology, Scripps Research; La Jolla, CA, USA.ORCID 0000-0003-4053-4835
Yonghong BaiMOMA Therapeutics, Cambridge, MA, USA.
Brian A Sosa-AlvaradoMOMA Therapeutics, Cambridge, MA, USA.
Timothy GuziMOMA Therapeutics, Cambridge, MA, USA.
Gabriel C LanderDepartment of Integrative Structural and Computational Biology, Scripps Research; La Jolla, CA, USA.ORCID 0000-0003-4921-1135

Funding

High-speed direct detector for cryo electron microscopyS10OD032467 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI LANDER, GABRIEL C · 2022 to 2022
$600k
Elucidation of the Mechanism of Microhomology-Mediated End Joining by DNA Polymerase ThetaF32CA288144 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI ZERIO, CHRISTOPHER JOHN · 2024 to 2024
$74k
NCI NIH HHS F32 CA288144NIH HHS S10 OD032467
6 · The paper itself

Abstract

DNA double-strand breaks occur in all human cells on a daily basis and must be repaired with high fidelity to minimize genomic instability

Identifiers

PMID38712090
PMCPMC11071473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.