Evidence map›Paper›PMID 38712080›Full record

ArticlebioRxiv : the preprint server for biology2024

Protection against experimental cryptococcosis elicited by Cationic Adjuvant Formulation 01-adjuvanted subunit vaccines.

Ruiying Wang, Lorena V N Oliveira, Maureen M Hester, Diana Carlson, Dennis Christensen, Charles A Specht, Stuart M Levitz

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ruiying WangDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Lorena V N OliveiraDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Maureen M HesterDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Diana CarlsonDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Dennis ChristensenStatens Serum Institut, Copenhagen, Denmark.
Charles A SpechtDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Stuart M LevitzDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-3799-3064

Funding

Preclinical studies of a Cryptococcus vaccine for AIDS patientsR01AI125045 · NIAID · WASHINGTON UNIVERSITY · PI LEVITZ, STUART MICHAEL, LODGE, JENNIFER K. · 2016 to 2025
$7.1M
Large Scale T Cell Epitope Discovery75N93019C00064 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAGE, KASIA · 2019 to 2024
$6.3M
A subunit Cryptococcus vaccineR01AI172154 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Stuart Michael Levitz · 2022 to 2026
$3.1M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
NIAID NIH HHS 75N93019C00064NIAID NIH HHS R01 AI125045NIAID NIH HHS R01 AI172154NIAID NIH HHS T32 AI095213
6 · The paper itself

Abstract

The fungal infection, cryptococcosis, is responsible for >100,000 deaths annually. No licensed vaccines are available. We explored the efficacy and immune responses of subunit cryptococcal vaccines adjuvanted with Cationic Adjuvant Formulation 01 (CAF01). CAF01 promotes humoral and T helper (Th) 1 and Th17 immune responses and has been safely used in human vaccine trials. Four subcutaneous vaccines, each containing single recombinant

Indexed as

adjuvantCAF01CD4+ T cellsCryptococcusefficacyimmune responsevaccine

Identifiers

PMID38712080
PMCPMC11071535

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.