Evidence map›Paper›PMID 38712078›Full record

ArticlebioRxiv : the preprint server for biology2024

A dynamic compositional equilibrium governs mRNA recognition by eIF3.

Nicholas A Ide, Riley C Gentry, Margaret A Rudbach, Kyungyoon Yoo, Paloma Kai Velez, Victoria M Comunale, Erik W Hartwick, Colin D Kinz-Thompson, Ruben L Gonzalez, Colin Echeverría Aitken

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas A IdeDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Riley C GentryDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Margaret A RudbachBiochemistry Program, Vassar College, Poughkeepsie, NY, USA.ORCID 0009-0007-4685-9506
Kyungyoon YooBiochemistry Program, Vassar College, Poughkeepsie, NY, USA.ORCID 0000-0002-5223-0882
Paloma Kai VelezBiochemistry Program, Vassar College, Poughkeepsie, NY, USA.
Victoria M ComunaleDepartment of Chemistry, Columbia University, New York, NY, USA.
Erik W HartwickDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID 0000-0001-9276-8567
Colin D Kinz-ThompsonDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID 0000-0002-2636-7893
Ruben L GonzalezDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID 0000-0002-1344-5581
Colin Echeverría AitkenBiochemistry Program, Vassar College, Poughkeepsie, NY, USA.ORCID 0000-0003-2187-0614

Funding

The Structural Dynamics of Translation InitiationR01GM084288 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GONZALEZ, RUBEN L · 2009 to 2022
$4.4M
The Structural Dynamics of Translation and Translational ControlR35GM153724 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Ruben L Gonzalez · 2024 to 2026
$2.4M
The mechanism and regulation of mRNA recruitment during eukaryotic translation initiationR01CA277727 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Ruben L Gonzalez · 2023 to 2026
$1.3M
THE ROLE OF THE mRNA-ENTRY-CHANNEL ARM OF eIF3 IN mRNA RECRUITMENTR15GM140372 · NIGMS · VASSAR COLLEGE · PI AITKEN, COLIN · 2020 to 2024
$807k
The Conformational Dynamics of eIF5B During Ribosomal Subunit JoiningF32GM139360 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HARTWICK, ERIK W · 2020 to 2022
$128k
NCI NIH HHS R01 CA277727NIGMS NIH HHS F32 GM139360NIGMS NIH HHS R01 GM084288NIGMS NIH HHS R15 GM140372NIGMS NIH HHS R35 GM153724
6 · The paper itself

Abstract

Eukaryotic translation initiation factor (eIF) 3 is a multi-subunit protein complex that binds both ribosomes and messenger RNAs (mRNAs) to drive a diverse set of mechanistic steps during translation of an mRNA into the protein it encodes. And yet, a unifying framework explaining how eIF3 performs these numerous activities is lacking. Using single-molecule light scattering microscopy, we demonstrate that

Indexed as

biochemistrybiophysicseIF3mass photometrymRNAmRNA recruitmentribosomesingle-moleculeTranslationtranslational regulationtranslation initiation

Identifiers

PMID38712078
PMCPMC11071631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.