Evidence map›Paper›PMID 38712058›Full record

ArticlebioRxiv : the preprint server for biology2025

Improved specificity and efficiency of

Madelynn N Whittaker, Lauren C Testa, Dominique L Brooks, Aidan Quigley, Hooda Said, Garima Dwivedi, Ishaan Jindal, Daphne Volpp, Ping Qu, Josh Zhiyong Wang and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Madelynn N WhittakerCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lauren C TestaCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Dominique L BrooksCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Aidan QuigleyCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hooda SaidDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Garima DwivediDivision of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ishaan JindalCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Daphne VolppCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ping QuCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Josh Zhiyong WangAgilent Technologies, Inc., Santa Clara, California, USA.
Michael A LevineDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Rebecca C Ahrens-NicklasDepartment of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Qiaoli LiDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Kiran MusunuruCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3298-0368
Mohamad-Gabriel AlamehDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
William H PeranteauThe Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Xiao WangCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Replication study of in vivo postnatal gene editing for metabolic liver disease in the nonhuman primate modelU19NS132301 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Kiran Musunuru · 2023 to 2026
$48.5M
Diagnosis, Prevention, And Treatment Of Cardiovascular Diseases With Genome EditingR35HL145203 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUSUNURU, KIRAN · 2019 to 2025
$5.7M
In utero CRISPR-mediated gene editing to cure congenital monogenic disordersDP2HL152427 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI PERANTEAU, WILLIAM H. · 2019 to 2019
$2.6M
Corrective editing to treat phenylketonuriaR01HD110733 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Xiao Wang · 2024 to 2026
$2.0M
Gene Therapy for PXE: Breaking the Barrier of Ectopic CalcificationR21AR084212 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI LI, QIAOLI · 2024 to 2025
$357k
NHLBI NIH HHS DP2 HL152427NHLBI NIH HHS R35 HL145203NIAMS NIH HHS R21 AR084212NICHD NIH HHS R01 HD110733NINDS NIH HHS U19 NS132301
6 · The paper itself

Abstract

Phenylketonuria (PKU), pseudoxanthoma elasticum (PXE), and hereditary tyrosinemia type 1 (HT1) are autosomal recessive disorders linked to the

Identifiers

PMID38712058
PMCPMC11071363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.