Evidence map›Paper›PMID 38712049›Full record

ArticlebioRxiv : the preprint server for biology2024

Mild Hyperthermia Enhanced Liposomal Doxorubicin Delivery and CD8

Farzaneh Rezazadeh, Wajfa Saadat, Ryan Smith, Alexander Pattyn, Mohammad Malik, Fuad Yazdani, Allen-Dexter Saliganan, Mohammad Mehrmohammadi, Nerissa T Viola

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Farzaneh RezazadehDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201.
Wajfa SaadatDepartment of Biological Science, Wayne State University, Detroit, MI 48201.
Ryan SmithDepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA.
Alexander PattynDepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA.
Mohammad MalikDepartment of Kinesiology, Wayne State University, Detroit, MI 48201.
Fuad YazdaniDepartment of Public Health, Wayne State University, Detroit, MI 48201.
Allen-Dexter SaligananDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201.
Mohammad MehrmohammadiDepartment of Imaging Sciences, University of Rochester Medical Center, Rochester, NY.
Nerissa T ViolaDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201.ORCID 0000-0003-4253-5639

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
Delineating Functional Immunity via Image-Guided PETR37CA220482 · NCI · WAYNE STATE UNIVERSITY · PI GIBSON, HEATHER MARIE, VIOLA, NERISSA THERESE · 2018 to 2024
$3.9M
NCI NIH HHS P30 CA022453NCI NIH HHS R37 CA220482
6 · The paper itself

Abstract

Mild hyperthermia (MHTh) is often used in combination with chemotherapy and radiotherapy for cancer treatment. In the current study, the effect of MHTh on the enhanced uptake of the FDA-approved chemotherapy drug, liposomal doxorubicin (dox) in syngeneic 4T1 tumors was investigated. Doxorubicin has inherent fluorescence properties having an emission signal at 590 nm upon excitation with a 480 nm laser. A group of mice administered with doxorubicin (dox) were exposed to MHTh (42 °C) for 30 minutes whereas control group given dox did not receive MHTh.

Identifiers

PMID38712049
PMCPMC11071532

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.