ArticleFrontiers in immunology2024
Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma.
Abstract readMulticenter Study
In one paragraph
Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18citing papers in PubMed, 1 pooled it
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The clinical and pathological histology efficacy of biological therapy for severe asthma with a phenotype of type 2 inflammation - systematic review.Frontiers in immunology · 2025Pooled it
- Small airway dysfunction as a functional barrier to spirometry-defined clinical remission in severe asthma treated with biologic therapies.The World Allergy Organization journal · 2026Article
- The Use of Biological Therapies in the Treatment of Chronic Rhinosinusitis with Nasal Polyps: Current State of Knowledge.Journal of clinical medicine · 2026Review
- Twelve-Month Real-World Outcomes of Tezepelumab in Severe Asthma: Clinical Remission, Biomarker Changes, and Trigger Burden-A SANI Multicenter Cohort.Journal of personalized medicine · 2026Article
- Observational
- Inflammatory score, intrinsic capacity and the risk of new-onset chronic lung disease: a cohort study from the China Health and Retirement Longitudinal Study.Journal of thoracic disease · 2026Article
- From FEVJournal of asthma and allergy · 2026Review
- Association of Easier Biologic Access with Remission and Other Clinical Outcomes in Severe Asthma: A Global Real-World Study.Journal of asthma and allergy · 2026Article
- Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR).The World Allergy Organization journal · 2025Article
- Machine learning-based model for acute asthma exacerbation detection using routine blood parameters.The World Allergy Organization journal · 2025Article
- International Severe Asthma Registry (ISAR): 2017-2024 Status and Progress Update.Tuberculosis and respiratory diseases · 2025Article
- Eosinophil-Driven vs. Eosinophil-Associated Severe Asthma: Practical Implications for Target Treatment.International journal of molecular sciences · 2025Review
- Advances in Biologic Therapies for Allergic Diseases: Current Trends, Emerging Agents, and Future Perspectives.Journal of clinical medicine · 2025Review
- Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity.Journal of asthma and allergy · 2025Article
- Exploring the pathogenesis and clinical implications of asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO): a narrative review.Frontiers in medicine · 2025Review
- Endotype-driven decisions in choosing a biologic for airway diseases.Frontiers in allergy · 2025Review
- Real-World Biologic Use Patterns in Severe Asthma, 2015-2021: The CLEAR Study.Pragmatic and observational research · 2025Article
- Burden of Type 2 and Oral Corticosteroids Related Comorbidities in Severe Asthma Patients from the Gulf Countries: A Comparative Study from The ISAR Registry.Journal of asthma and allergy · 2025Article
Corrections and comments
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Authors and funding
87 authors.
Celeste M PorsbjergDepartment of Respiratory Medicine and Infectious Diseases, Research Unit, Bispebjerg Hospital, Copenhagen, Denmark.
John TownendObservational and Pragmatic Research Institute, Singapore, Singapore.
Celine BergeronDepartment of Medicine, Centre for Lung Health, Vancouver General Hospital, Vancouver, BC, Canada.
George C ChristoffFaculty of Public Health, Medical University, Sofia, Bulgaria.
Gregory P KatsoulotosWoolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.
Désirée Larenas-LinnemannCentro de Excelencia en Asma y Alergia, Hospital Médica Sur, Ciudad de México, Mexico.
Trung N TranBioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, United States.
Riyad Al-LehebiDepartment of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia.
Sinthia Z Bosnic-AnticevichWoolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.
John BusbyCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Mark HewAllergy, Asthma and Clinical Immunology Service, Alfred Health, Melbourne, VIC, Australia.
Konstantinos KostikasRespiratory Medicine Department, University of Ioannina, Ioannina, Greece.
Nikolaos G PapadopoulosDivision of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom.
Paul E PfefferDepartment of Respiratory Medicine, Barts Health National Health Services (NHS) Trust, London, United Kingdom.
Todor A PopovUniversity Hospital St. Ivan Rilski, Sofia, Bulgaria.
Chin Kook RheeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Mohsen SadatsafaviRespiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
Ming-Ju TsaiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Charlotte Suppli UlrikDepartment of Respiratory Medicine, Copenhagen ;University Hospital - Hvidovre, Copenhagen, Denmark.
Mona Al-AhmadMicrobiology Department, College of Medicine, Kuwait University, Kuwait City, Kuwait.
Alan AltrajaDepartment of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia.
Aaron BeastallObservational and Pragmatic Research Institute, Singapore, Singapore.
Lakmini BulathsinhalaObservational and Pragmatic Research Institute, Singapore, Singapore.
Victoria CarterObservational and Pragmatic Research Institute, Singapore, Singapore.
Borja G CosioSon Espases University Hospital-Institut d'Investigació Sanitària Illes Balears (IdISBa)-Ciberes, Mallorca, Spain.
Kirsty FlettonObservational and Pragmatic Research Institute, Singapore, Singapore.
Susanne HansenRespiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark.
Liam G HeaneyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Richard B HubbardObservational and Pragmatic Research Institute, Singapore, Singapore.
Piotr KunaDivision of Internal Medicine Asthma and Allergy, Medical University of Lodz, Lodz, Poland.
Ruth B MurrayOptimum Patient Care Global, Cambridge, United Kingdom.
Tatsuya NaganoDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Laura PiniDepartment of Clinical and Experimental Sciences - University of Brescia, Spedali Civili di Brescia, Brescia, Italy.
Diana Jimena Cano RosalesInstituto Neumológico del Oriente, Bucaramanga, Colombia.
Florence SchleichCentre Hospitalier Universitaire (CHU) Sart-Tilman, GIGA I3, University of Liege, Liège, Belgium.
Michael E WechslerDepartment of Medicine, National Jewish Health (NJH) Cohen Family Asthma Institute, National Jewish Health, Denver, CO, United States.
Rita AmaralDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Arnaud BourdinPhyMedExp, Univ Montpellier, National Center for Scientific Research (CNRS), The National Institute of Health and Medical Research (INSERM), Centre Hospitalier Universitaire (CHU) Montpellier, Montpellier, France.
Guy G BrusselleDepartment of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Wenjia ChenSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Li Ping ChungDepartment of Respiratory Medicine, Fiona Stanley Hospital, Perth, WA, Australia.
Eve DentonAllergy, Asthma and Clinical Immunology Service, Alfred Health, Melbourne, VIC, Australia.
Joao A FonsecaCINTESIS@RISE, MEDCIDS, Faculty of Medicine of the University of Porto, Porto, Portugal.
Flavia HoyteDivision of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, United States.
David J JacksonGuy's Severe Asthma Centre, Guy's Hospital, King's College London, London, United Kingdom.
Rohit KatialDivision of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, United States.
Bruce J KirengaDepartment of Medicine, Lung Institute, Makerere University Lung Institute, Kampala, Uganda.
Mariko Siyue KohDepartment of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore, Singapore.
Agnieszka ŁawkiedrajMedical University of Lodz, Lodz, Poland.
Lauri LehtimäkiAllergy Centre, Tampere University Hospital, Tampere, Finland.
Mei Fong LiewFAST and Chronic Programmes, Alexandra Hospital, National University Health System, Singapore, Singapore.
Bassam MahboubRashid Hospital, Dubai Health Authority (DHA), Dubai, United Arab Emirates.
Neil MartinBioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, United States.
Andrew N Menzies-GowBioPharmaceutical Medical, AstraZeneca, Cambridge, United Kingdom.
Pee Hwee PangDepartment of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
Andriana I Papaioannou2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, Greece.
Pujan H PatelRespiratory Medicine, Royal Brompton Hospital, London, United Kingdom.
Luis Perez-De-LlanoPneumology Service, Lucus Augusti University Hospital, Sergas (Galician Healthcare Service) Integrated Management Structure (EOXI) Lugo, Cervo, Spain.
Matthew J PetersDepartment of Thoracic Medicine, Concord Hospital, Sydney, NSW, Australia.
Luisa RicciardiAllergy and Clinical Immunology, G. Martino Hospital, University of Messina, Messina, Italy.
Bellanid Rodríguez-CáceresInstituto Neumológico del Oriente, Bucaramanga, Colombia.
Ivan SolartePulmonary Unit, Hospital Universitario San Ignacio, Bogotá, Colombia.
Tunn Ren TayDepartment of Respiratory and Critical Care Medicine, Changi General Hospital, Singapore, Singapore.
Carlos A Torres-DuqueCentro Internacional de Investigación en Neumología (CINEUMO), Respiratory Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia.
Eileen WangDivision of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, United States.
Martina ZappaDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
John AbisheganadenDepartment of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
Karin Dahl AssingDepartment of Respiratory Medicine, Aalborg University Hospital, Aalborg, Denmark.
Richard W CostelloDepartment of Respiratory Medicine, Clinical Research Centre, Smurfit Building Beaumont Hospital, Royal College of Surgeons Ireland (RCSI), Dublin, Ireland.
Peter G GibsonAustralian Severe Asthma Network, Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, NSW, Australia.
Enrico HefflerPersonalized Medicine, Asthma and Allergy, Istituto Clinico Humanitas, Humanitas Cancer Center (IRCCS) Humanitas Research Hospital, Rozzano, Italy.
Jorge MásperoClinical Research for Allergy and Respiratory Medicine, CIDEA Foundation, Buenos Aires, Argentina.
Stefania NicolaAllergy and Immunology Unit, L'Azienda Ospedaliera (AO) Ordine Mauriziano di Torino, Turin, Italy.
Diahn-Warng Perng SteveSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Francesca PuggioniPersonalized Medicine, Asthma and Allergy, Istituto Clinico Humanitas, Humanitas Cancer Center (IRCCS) Humanitas Research Hospital, Rozzano, Italy.
Sundeep SalviPulmocare Research and Education Foundation, Pune, India.
Chau-Chyun SheuDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Concetta SirenaSevere Asthma Network Italy (SANI), Milano, Italy.
Camille TailléDepartment of Respiratory Diseases, Bichat Hospital, l'Assistance publique - Hôpitaux de Paris (AP-HP) Nord-Université Paris Cité, Paris, France.
Tze Lee TanDepartment of Family Medicine, National University Health System, Singapore, Singapore.
Leif BjermerRespiratory Medicine and Allergology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden.
Giorgio Walter CanonicaPersonalized Medicine, Asthma and Allergy, Istituto Clinico Humanitas, Humanitas Cancer Center (IRCCS) Humanitas Research Hospital, Rozzano, Italy.
Takashi IwanagaKindai University Hospital, Osakasayama, Japan.
Libardo Jiménez-MaldonadoFundación Neumológica Colombiana, ASMAIRE REXPIRA (Atención integral y rehabilitación en asma or Comprehensive Care and Rehabilitation in Asthma) Program, Bogotá, Colombia.
Christian TaubeDepartment of Pulmonary Medicine, University Medical Center Essen-Ruhrlandklinik, Essen, Germany.
Luisa BrussinoDepartment of Medical Sciences, University of Turin, Turin, Italy.
David B PriceObservational and Pragmatic Research Institute, Singapore, Singapore.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials. Aim: To elucidate the associations of pre-biologic individual biomarker levels or their combinations with pre-to-post biologic changes in asthma outcomes in real-life. Methods: This was a registry-based, cohort study using data from 23 countries, which shared data with the International Severe Asthma Registry (May 2017-February 2023). The investigated biomarkers (highest pre-biologic levels) were immunoglobulin E (IgE), blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO). Pre- to approximately 12-month post-biologic change for each of three asthma outcome domains (i.e. exacerbation rate, symptom control and lung function), and the association of this change with pre-biologic biomarkers was investigated for individual and combined biomarkers. Results: Overall, 3751 patients initiated biologics and were included in the analysis. No association was found between pre-biologic BEC and pre-to-post biologic change in exacerbation rate for any biologic class. However, higher pre-biologic BEC and FeNO were both associated with greater post-biologic improvement in FEV Conclusions: The ability of higher baseline BEC, FeNO and their combination to predict biologic-associated lung function improvement may encourage earlier intervention in patients with impaired lung function or at risk of accelerated lung function decline.
Indexed as
AsthmaBiological ProductsBiomarkersEosinophilsImmunoglobulin EAdultAgedAnti-Asthmatic AgentsCohort StudiesFemaleHumansLeukocyte CountMaleMiddle AgedNitric OxideRegistriesAnti-Asthmatic AgentsBiological ProductsBiomarkersImmunoglobulin ENitric Oxidebiologicsbiomarkerseosinophil (EOS)FeNO (Fraction of exhaled Nitric Oxide)FEV1personalized medicine (PM)severe asthma
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