Evidence map›Paper›PMID 38711387›Full record

ArticleChemMedChem2024

Naphtho[1,8-ef]isoindole-7,8,10(9H)-trione as Novel Theranostic Agents for Photodynamic Therapy and Multi-Subcellular Organelles Localization.

Shaoying Tan, Qiqi Fu, Kecheng Lei, Wenyi Mei, Jianwen Liu, Xuhong Qian, Yufang Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shaoying TanShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Qiqi FuShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Kecheng LeiState Key Laboratory of Bioreactor Engineering & Shanghai Key Laboratory of New Drug Design, Biomedical Nanotechnology Center, School of pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Wenyi MeiShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Jianwen LiuState Key Laboratory of Bioreactor Engineering & Shanghai Key Laboratory of New Drug Design, Biomedical Nanotechnology Center, School of pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Xuhong QianShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Yufang XuShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.ORCID https://orcid.org/0000-0003-4946-4722

Funding

National Key Research and Development Programs 2022YFD1700403National Key Research and Development Programs 2023YFD1700303
6 · The paper itself

Abstract

A series of naphtho[1,8-ef]isoindole-7,8,10(9H)-trione derivatives as novel theranostic agents for photodynamic therapy and multi-subcellular organelles localization were designed and synthesized. Most of them possess moderate fluorescence quantum yield and long wavelength absorption simultaneously, which made them possible for dual effects of imaging and therapy. Notably, compounds 7 b and 7 d exhibited significant light-toxicity but slight dark-toxicity. Confocal fluorescence microscopy experiments demonstrated that compound 7 b can locate and image in special multi-subcellular organelles. All the research results implied that naphtho[1,8-ef] isoindole-7,8,10(9H)-trione derivatives can be applied as a new series of theranostic agents with the characteristics of photodynamic therapy and multi-subcellular organelles imaging.

Indexed as

OrganellesPhotochemotherapyPhotosensitizing AgentsTheranostic NanomedicineAntineoplastic AgentsCell ProliferationCell SurvivalDose-Response Relationship, DrugHeLa CellsHumansIsoindolesMolecular StructureNaphthalenesStructure-Activity RelationshipAntineoplastic AgentsIsoindolesNaphthalenesPhotosensitizing Agentsimagingmulti-subcellular organellesnaphtho[1,8-ef]isoindole-7,8,10(9H)-trionephotodynamic therapytheranostic agent

Identifiers

PMID38711387
PMCPMC13494807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.