Evidence map›Paper›PMID 38711299›Full record

ReviewStress (Amsterdam, Netherlands)2024

The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.

Rachel Gilgoff, Summer Mengelkoch, Jorina Elbers, Krista Kotz, Arielle Radin, Isha Pasumarthi, Reanna Murthy, Sayantani Sindher, Nadine Burke Harris, George M Slavich

Abstract readReview
In one paragraph

Review in Stress (Amsterdam, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study.Autism : the international journal of research and practice · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rachel GilgoffSean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, CA, USA.ORCID 0000-0002-1265-2925
Summer MengelkochDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.ORCID 0000-0002-1845-2107
Jorina ElbersTrauma Recovery Program, HeartMath Institute, Boulder Creek, CA, USA.ORCID 0000-0002-7509-8909
Krista KotzKotz Consulting, Moraga, CA, USA.ORCID 0009-0007-5528-3641
Arielle RadinBruin Health Inc., Santa Barbara, CA, USA.ORCID 0000-0002-7100-1081
Isha PasumarthiSean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, CA, USA.ORCID 0000-0001-7479-1050
Reanna MurthySean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, CA, USA.ORCID 0009-0006-0238-6324
Sayantani SindherSean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, CA, USA.ORCID 0000-0003-0387-2800
Nadine Burke HarrisACE Resource Network, Laguna Hills, CA, USA.ORCID 0000-0002-5395-193X
George M SlavichDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.ORCID 0000-0001-5710-3818

Funding

Neural, Inflammatory, and Genomic Mechanisms Underlying Risk for Depression in AdolescenceK08MH103443 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLAVICH, GEORGE MICHAEL · 2015 to 2018
$772k
NIMH NIH HHS K08 MH103443
6 · The paper itself

Abstract

Although dysregulated stress biology is becoming increasingly recognized as a key driver of lifelong disparities in chronic disease, we presently have no validated biomarkers of toxic stress physiology; no biological, behavioral, or cognitive treatments specifically focused on normalizing toxic stress processes; and no agreed-upon guidelines for treating stress in the clinic or evaluating the efficacy of interventions that seek to reduce toxic stress and improve human functioning. We address these critical issues by (a) systematically describing key systems and mechanisms that are dysregulated by stress; (b) summarizing indicators, biomarkers, and instruments for assessing stress response systems; and (c) highlighting therapeutic approaches that can be used to normalize stress-related biopsychosocial functioning. We also present a novel multidisciplinary Stress Phenotyping Framework that can bring stress researchers and clinicians one step closer to realizing the goal of using precision medicine-based approaches to prevent and treat stress-associated health problems.

Indexed as

PhenotypeStress, PhysiologicalStress, PsychologicalBiomarkersHumansPrecision MedicineBiomarkersbiomarkerearly life adversityinterventionLife stressscreeningtoxic stresstreatment

Identifiers

PMID38711299
PMCPMC11219250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.