ArticleCritical care (London, England)2024
Sepsis mortality among patients with haematological malignancy admitted to intensive care 2000-2022: a binational cohort study.
Article in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Impact of immunosuppression on the incidence of ventilator-associated events: an observational study.BMC anesthesiology · 2026Observational
- Age-Comorbidity Interactions and Clinical Outcomes in Septic Shock: An Emergency Department-Based Multicenter Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Short-term mortality after intensive care admission in acute lymphoblastic versus predominantly acute myeloid leukemia: a retrospective cohort study using MIMIC-IV with eICU external replication.Frontiers in oncology · 2026Article
- Factors associated with treatment resumption and long-term outcomes after ICU discharge in patients with hematological malignancies.Annals of intensive care · 2026Article
- Deriving consensus sepsis clusters via goal-directed subgroup identification in multi-omics study.Nature communications · 2025Article
- Mortality Trends and Demographic Disparities Among Patients With Lymphoid Leukemia and Septicemia.Cureus · 2025Article
- Sepsis detection in hematologic and solid tumor malignancies using quantitative inflammatory biomarker differences in a prospective single center study.Scientific reports · 2025Observational
- Septic Shock in Hematological Malignancies: Role of Artificial Intelligence in Predicting Outcomes.Current oncology (Toronto, Ont.) · 2025Review
- Sepsis in elderly patients: investigation of prognostic factors in a secondary healthcare facility.BMC infectious diseases · 2025Article
- Clinical characteristics and prognostic factors of sepsis in patients with malignancy.Scientific reports · 2025Observational
- Authors' response to: Relationship between leukopenia and mortality among patients with haematological malignancies.Critical care (London, England) · 2025Article
- [The value of sequential organ failure assessment and its dynamic changes in predicting mortality in hematology intensive care unit].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Personalized ICU mortality assessment by interpretable machine learning algorithms in patients with sepsis combined lung cancer: a population-based study and an external validation cohort.Frontiers in oncology · 2025Article
- Colistimethate sodium is efficacious and safe for the management of sepsis in hematological diseases patients: a retrospective study in China.Frontiers in cellular and infection microbiology · 2025Article
- Relationship between leukopenia and mortality among patients with hematological malignancies.Critical care (London, England) · 2024Article
- Septic shock in the immunocompromised cancer patient: a narrative review.Critical care (London, England) · 2024Review
- Differences in the relative importance of predictors of short- and long-term mortality among critically ill patients with cancer.Critical care science · 2024Article
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Abstract
backgroundSepsis occurs in 12-27% of patients with haematological malignancy within a year of diagnosis. Sepsis mortality has improved in non-cancer patients in the last two decades, but longitudinal trends in patients with haematological malignancy are not well characterised. We aimed to compare outcomes, including temporal changes, in patients with and without a haematological malignancy admitted to ICU with a primary diagnosis of sepsis in Australia and New Zealand over the past two decades.
methodsWe performed a retrospective cohort study of 282,627 patients with a primary intensive care unit (ICU) admission diagnosis of sepsis including 17,313 patients with haematological malignancy, admitted to 216 intensive care units (ICUs) in Australia or New Zealand between January 2000 and December 2022. Annual crude and adjusted in-hospital mortality were reported. Risk factors for in-hospital mortality were determined using a mixed methods logistic regression model and were used to calculate annual changes in mortality.
resultsIn-hospital sepsis mortality decreased in patients with haematological malignancy, from 55.6% (95% CI 46.5-64.6%) in 2000 to 23.1% (95% CI 20.8-25.5%) in 2021. In patients without haematological malignancy mortality decreased from 33.1% (95% CI 31.3-35.1%) to 14.4% (95% CI 13.8-14.8%). This decrease remained significant after adjusting for mortality predictors including age, SOFA score and comorbidities, as estimated by adjusted annual odds of in-hospital death. The reduction in odds of death was of greater magnitude in patients with haematological malignancy than those without (OR 0.954, 95% CI 0.947-0.961 vs. OR 0.968, 95% CI 0.966-0.971, p < 0.001). However, absolute risk of in-hospital mortality remained higher in patients with haematological malignancy. Older age, higher SOFA score, presence of comorbidities, and mechanical ventilation were associated with increased mortality. Leukopenia (white cell count < 1.0 × 10
conclusionsSepsis mortality has improved in patients with haematological malignancy admitted to ICU. However, mortality remains higher in patients with haematological malignancy than those without.
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