Evidence map›Paper›PMID 38711118›Full record

ArticleFluids and barriers of the CNS2024

The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells.

Nana Svane, Alberte Bay Villekjær Pedersen, Anne Rodenberg, Burak Ozgür, Lasse Saaby, Christoffer Bundgaard, Mie Kristensen, Peer Tfelt-Hansen, Birger Brodin

Abstract read
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In one paragraph

Article in Fluids and barriers of the CNS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Unveiling the sumatriptan dose-relief relationship.European journal of clinical pharmacology · 2026
    Article
  2. Comparative analysis of the uptake of the HFluids and barriers of the CNS · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nana SvaneDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Alberte Bay Villekjær PedersenDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Anne RodenbergDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Burak OzgürDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Lasse SaabyDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Christoffer BundgaardTranslational DMPK, H. Lundbeck A/S, Valby, Denmark.
Mie KristensenDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Peer Tfelt-HansenDanish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.
Birger BrodinDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark. birger.brodin@sund.ku.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTriptans are anti-migraine drugs with a potential central site of action. However, it is not known to what extent triptans cross the blood-brain barrier (BBB). The aim of this study was therefore to determine if triptans pass the brain capillary endothelium and investigate the possible underlying mechanisms with focus on the involvement of the putative proton-coupled organic cation (H

methodsWe investigated the cellular uptake characteristics of the prototypical H

resultsWe demonstrated that most triptans were able to inhibit uptake of the H

conclusionsWe have demonstrated that the triptan family of compounds possesses affinity for the H

Indexed as

Blood-Brain BarrierBrainEndothelial CellsMice, KnockoutPyrrolidinesTryptaminesAnimalsAntiportersATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Biological TransportCell LineHumansMaleMiceMice, Inbred C57BLAntiportersATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1eletriptanmultidrug resistance protein 3PyrilaminePyrrolidinesTryptaminesActive uptakeBlood–brain barrierCapillary endotheliumMigraine treatmentOxycodone transporterP-glycoproteinProton-coupled organic cation antiporterTriptans

Identifiers

PMID38711118
PMCPMC11071266

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.