Evidence map›Paper›PMID 38710949›Full record

ArticleNature medicine2024

APOE4 homozygosity is a new genetic form of Alzheimer's disease.

Qin Xu, Zherui Liang, Yadong Huang

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Qin XuGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Zherui LiangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Yadong HuangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA. yadong.huang@gladstone.ucsf.edu.ORCID 0000-0002-5871-4589

Funding

Project 4: Cross-species Dissection of Cellular Response to APOE Genotype and AD Pathology Using Single-cell Multi-omicsP01AG073082 · NIA · J. DAVID GLADSTONE INSTITUTES · PI HUANG, YADONG, MUCKE, LENNART · 2021 to 2025
$23.4M
Study Susceptibility and Resistance to ApoE4 in Alzheimer's DiseaseRF1AG076647 · NIA · J. DAVID GLADSTONE INSTITUTES · PI HUANG, YADONG · 2022 to 2022
$2.6M
NIA NIH HHS P01 AG073082NIA NIH HHS RF1 AG076647
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseApolipoprotein E4HomozygoteGenetic Predisposition to DiseaseHumansApolipoprotein E4

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.