Evidence map›Paper›PMID 38710891›Full record

ArticleMolecular biology reports2024

Targeting c-Myc with decoy oligodeoxynucleotide-loaded polycationic nanoparticles inhibits cell growth and induces apoptosis in cancer stem-like cells (NTERA-2).

Roghayeh Ghorbani, Mahmoud Gharbavi, Benyamin Keshavarz, Hamid Madanchi, Behrooz Johari

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roghayeh Ghorbani *Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Mahmoud GharbaviNanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Benyamin KeshavarzStudent Research Committee, Zanjan University of Medical Sciences, Zanjan, Iran.
Hamid MadanchiNervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran. hamidmadanchi@yahoo.com.
Behrooz Johari *Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Behroozjohari@yahoo.com.

Funding

Zanjan University of Medical Sciences Grant Number: A-12-1244-24 & Ethical Code: IR.ZUMS.BLC.1402.014
6 · The paper itself

Abstract

backgroundAn increase in cancer stem cell (CSC) populations and their resistance to common treatments could be a result of c-Myc dysregulations in certain cancer cells. In the current study, we investigated anticancer effects of c-Myc decoy ODNs loaded-poly (methacrylic acid-co-diallyl dimethyl ammonium chloride) (PMA-DDA)-coated silica nanoparticles as carriers on cancer-like stem cells (NTERA-2). METHODS AND

resultsThe physicochemical characteristics of the synthesized nanocomposites (SiO

conclusionsThe conclusion drawn from this study is that c-Myc decoy ODN-loaded SiO

Indexed as

ApoptosisCell ProliferationNanoparticlesNeoplastic Stem CellsProto-Oncogene Proteins c-mycCell CycleCell Line, TumorCell SurvivalHumansNanocompositesOligodeoxyribonucleotidesPolyaminesPolyelectrolytesSilicon DioxideMYC protein, humanOligodeoxyribonucleotidesPolyaminesPolyelectrolytesProto-Oncogene Proteins c-mycSilicon Dioxidec-Myc transcription factorDecoy ODNsNTERA-2 cancer cellPolycationic nanoparticleSilica nanoparticles

Identifiers

PMID38710891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.