Evidence map›Paper›PMID 38710832›Full record

ArticleScientific reports2024

Detection of clonal plasma cells in POEMS syndrome using multiparameter flow cytometry.

Arata Ishii, Shokichi Tsukamoto, Naoya Mimura, Yurie Miyamoto-Nagai, Yusuke Isshiki, Shinichiro Matsui, Sanshiro Nakao, Asuka Shibamiya, Yutaro Hino, Kensuke Kayamori and 11 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Arata IshiiDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Shokichi TsukamotoDepartment of Hematology, Chiba University Hospital, Chiba, Japan. shokichi.tsukamoto@chiba-u.jp.
Naoya MimuraDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Yurie Miyamoto-NagaiDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Yusuke IsshikiDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Shinichiro MatsuiDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Sanshiro NakaoDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Asuka ShibamiyaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Yutaro HinoDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Kensuke KayamoriDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Nagisa Oshima-HasegawaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Tomoya MutoDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Yusuke TakedaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Tomoki SuichiDepartment of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.
Sonoko MisawaDepartment of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.
Chikako OhwadaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.
Koutaro YokoteDepartment of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Satoshi KuwabaraDepartment of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan.
Chiaki NakasekoDepartment of Hematology, International University of Health and Welfare, Narita, Japan.
Hiroyuki TakamatsuDepartment of Hematology, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan.
Emiko SakaidaDepartment of Hematology, Chiba University Hospital, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein], and skin changes) is a rare systemic disorder characterized by various symptoms caused by underlying plasma cell (PC) dyscrasia. Detection of monoclonal PCs is mandatory for the diagnosis of POEMS syndrome; however, the usefulness of EuroFlow-based next-generation flow cytometry (EuroFlow-NGF) in POEMS syndrome for detecting monoclonal PCs in bone marrow (BM) and the gating strategy suitable for flow cytometry study of POEMS syndrome remain unknown. We employed EuroFlow-NGF-based single-tube eight-color multiparameter flow cytometry (MM-flow) and established a new gating strategy (POEMS-flow) to detect the monoclonal PCs in POEMS syndrome, gating CD38 broadly from dim to bright and CD45 narrowly from negative to dim compared to MM-flow. MM-flow detected monoclonal PCs in 9/25 (36.0%) cases, including 2/2 immunofixation electrophoresis (IFE)-negative cases (100%). However, POEMS-flow detected monoclonal PCs in 18/25 cases (72.0%), including 2/2 IFE-negative cases (100%). POEMS-flow detected monoclonal PCs with immunophenotypes of CD19

Indexed as

Flow CytometryPlasma CellsPOEMS SyndromeAdultAgedBone MarrowFemaleHumansImmunophenotypingMaleMiddle AgedEuroFlowImmunophenotypeMultiparameter flow cytometryPOEMS syndrome

Identifiers

PMID38710832
PMCPMC11074311

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