Evidence map›Paper›PMID 38710228›Full record

ArticleGesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))2025

[Early Detection Of Type 1 Diabetes By Islet Autoantibody Screening: A Position Paper Of The Fr1daplex Project Leaders And Training Centres, Bvkj Bavaria And Paednetz (Registered) Bavaria].

Peter Achenbach, Reinhard Berner, Ezio Bonifacio, Susanne Brämswig, Sonja Braig, Desiree Dunstheimer, Uwe Ermer, Dominik Ewald, Gita Gemulla, Julia Hauer and 17 more

Abstract readEnglish AbstractConsensus Statement
In one paragraph

Article in Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Peter AchenbachInstitut für Diabetesforschung, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.
Reinhard BernerUniversitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Kinder- und Jugendmedizin, Technische Universität Dresden, Dresden, Germany.
Ezio BonifacioCenter for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany.
Susanne BrämswigKlinik für Kinder- und Jugendmedizin, RoMed Klinikum Rosenheim, Rosenheim, Germany.
Sonja BraigKlinik für Kinder und Jugendliche, Klinikum Bayreuth GmbH, Bayreuth, Germany.
Desiree DunstheimerKlinik für Kinder- und Jugendmedizin, Universitätsklinikum Augsburg, Augsburg, Germany.
Uwe ErmerKinder- und Jugendmedizin, Ameos Klinikum St. Elisabeth Neuburg, Neuburg an der Donau, Germany.
Dominik EwaldBahnhofstr. 24, Kinderarztpraxis, Regensburg, Germany.
Gita GemullaUniversitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Kinder- und Jugendmedizin, Technische Universität Dresden, Dresden, Germany.
Julia HauerZentrum für Kinder und Jugendmedizin, München Klinik und Klinikum rechts der Isar, Technische Universität München Fakultät für Medizin, Munchen, Germany.
Florian HauptInstitut für Diabetesforschung, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.
Gabi HausHans-Mielich-Str. 35, Kinderarztpraxis, München, Germany.
Michael HubmannSteinweg 6, Kinderarztpraxis, Zirndorf, Germany.
Sandra HummelInstitut für Diabetesforschung, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.
Michael KandlerOttilienstr. 1, Kinderarztpraxis, Regensburg, Germany.
Olga KordonouriDiabetologie, Endokrinologie und Allgemeine Pädiatrie, Kinder- und Jugendkrankenhaus AUF DER BULT, Hannover, Germany.
Karin LangeMedizinische Psychologie, Medizinische Hochschule Hannover, Hannover, Germany.
Otto LaubHappinger Str. 98, Kinderarztpraxis, Rosenheim, Germany.
Anja LorrmannKinder und Jugendmedizin, KJF Klinik Josefinum GmbH, Augsburg, Germany.
Nicole Nellen-HellmuthKinderdiabetologie, MVZ Leopoldina GmbH, Schweinfurt, Germany.
Marina SindichakisKlinik für Kinder- und Jugendmedizin, Kinderdiabetologie, Klinikum Traunstein, Traunstein, Germany.
Thekla von dem BergeDiabetologie, Endokrinologie und Allgemeine Pädiatrie, Kinder- und Jugendkrankenhaus AUF DER BULT, Hannover, Germany.
Katharina WarnckeZentrum für Kinder und Jugendmedizin, München Klinik und Klinikum rechts der Isar, Technische Universität München Fakultät für Medizin, Munchen, Germany.
Leonie WeberKlinik für Kinderheilkunde und Jugendmedizin, Kinderdiabetologie, Klinikum Kempten-Oberallgau GmbH, Kempten, Germany.
Christiane WinklerInstitut für Diabetesforschung, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.
Philip WintermeyerIngolstädterstr. 166, Kinderarztpraxis, München, Germany.
Anette-Gabriele ZieglerInstitute of Diabetes Research, Helmholtz Center Munich German Research Center for Environmental Health, Neuherberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This position paper is based on the authors' many years of clinical experience and basic science research on the diagnosis and treatment of children and adolescents with a presymptomatic early stage of type 1 diabetes. The benefits as well as potential disadvantages of early detection of type 1 diabetes by islet autoantibody screening are critically discussed. In addition, the perspectives of delaying the onset of the clinical metabolic disease through treatment with teplizumab are addressed. Today, we see the chance for a relevant improvement in therapeutic options and life perspectives of affected children and adolescents. Important next steps for the implementation of islet autoantibody screening in Germany are the training of pediatricians who should inform families about the screening, establishment of a few transregional laboratories that carry out the test, and expansion of regional capacities for the training and care of children with an early stage of type 1 diabetes.

Indexed as

AutoantibodiesDiabetes Mellitus, Type 1Islets of LangerhansMass ScreeningPractice Guidelines as TopicAdolescentChildChild, PreschoolEarly DiagnosisFemaleGermanyHumansMaleSensitivity and SpecificityAutoantibodies

Identifiers

PMID38710228
PMCPMC11740224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.