Evidence map›Paper›PMID 38710015›Full record

ArticleNeurology2024

Reversibility of Cognitive Deficits and Functional Connectivity With Transfusion in Children With Sickle Cell Disease.

Landon C Power, Amy E Mirro, Micahel M Binkley, Jinli Wang, Kristin P Guilliams, Josiah B Lewis, Andria L Ford, Joshua S Shimony, Hongyu An, Jin-Moo Lee and 1 more

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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Landon C PowerFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.
Amy E MirroFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.
Micahel M BinkleyFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.
Jinli WangFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.
Kristin P GuilliamsFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-5518-3778
Josiah B LewisFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.
Andria L FordFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0003-0605-8943
Joshua S ShimonyFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-6228-776X
Hongyu AnFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0001-6459-2269
Jin-Moo LeeFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.
Melanie E FieldsFrom the Department of Pediatrics (L.C.P., A.E.M., M.M.B., K.P.G., M.E.F.), Center for Biostatistics and Data Science (J.W.), Department of Neurology (K.P.G., J.B.L., A.L.F., J.-M.L., M.E.F.), Mallinckrodt Institute of Radiology (K.P.G., A.L.F., J.S.S., H.A., J.-M.L.), and Department of Biomedical Engineering (J.-M.L.), Washington University School of Medicine, St. Louis, MO.ORCID 0000-0001-6223-4468

Funding

MR-Derived Cerebral Oxygen Metabolism underlying Ischemic Vulnerability in Sickle Cell DiseaseR01HL129241 · NHLBI · WASHINGTON UNIVERSITY · PI Hongyu An, Robert A Campbell · 2015 to 2026
$6.6M
MR measured regional hypoxia as an early biomarker in cerebral small vessel diseaseRF1NS116565 · NINDS · WASHINGTON UNIVERSITY · PI AN, HONGYU, FORD, ANDRIA LEE · 2020 to 2020
$3.4M
The Impact of Cerebral Metabolic Stress on the Development of the Structural and Functional Connectome in Pediatric Sickle Cell AnemiaR01HL157188 · NHLBI · WASHINGTON UNIVERSITY · PI FIELDS, MELANIE ERIN · 2021 to 2025
$3.1M
Mid-America Regional Coordinating Center (MARCC)U24NS107230 · NINDS · WASHINGTON UNIVERSITY · PI Andria Lee Ford, Peter David Panagos · 2018 to 2026
$2.8M
The role of metabolic and hemodynamic reserve in age-related brain vulnerability in pediatric sickle cell anemiaR01NS121065 · NINDS · WASHINGTON UNIVERSITY · PI GUILLIAMS, KRISTIN · 2021 to 2025
$2.4M
NHLBI NIH HHS R01 HL129241NHLBI NIH HHS R01 HL157188NINDS NIH HHS R01 NS121065NINDS NIH HHS RF1 NS116565NINDS NIH HHS U24 NS107230
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPeople with sickle cell disease (SCD) are at risk of cognitive dysfunction independent of stroke. Diminished functional connectivity in select large-scale networks and white matter integrity reflect the neurologic consequences of SCD. Because chronic transfusion therapy is neuroprotective in preventing stroke and strengthening executive function abilities in people with SCD, we hypothesized that red blood cell (RBC) transfusion facilitates the acute reversal of disruptions in functional connectivity while white matter integrity remains unaffected.

methodsChildren with SCD receiving chronic transfusion therapy underwent a brain MRI measuring white matter integrity with diffusion tensor imaging and resting-state functional connectivity within 3 days before and after transfusion of RBCs. Cognitive assessments with the NIH Toolbox were acquired after transfusion and then immediately before the following transfusion cycle.

resultsSixteen children with a median age of 12.5 years were included. Global assessments of functional connectivity using homotopy ( DISCUSSION: Strengthening of functional connectivity with concomitant improvement in executive function abilities with transfusion suggests that functional connectivity MRI could be used as a biomarker for acutely reversible neurocognitive injury as novel therapeutics are developed for people with SCD.

Indexed as

Anemia, Sickle CellCognitive DysfunctionDiffusion Tensor ImagingAdolescentBrainChildErythrocyte TransfusionExecutive FunctionFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysWhite Matter

Identifiers

PMID38710015
PMCPMC11177587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.