Evidence map›Paper›PMID 38709934›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones.

Jennifer A Smith, Benjamin T K Yuen, Whitney Purtha, Jared M Balolong, Jonah D Phipps, Frances Crawford, Jeffrey A Bluestone, John W Kappler, Mark S Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Induction of immune tolerance in NMOSD and MOGAD.Therapeutic advances in neurological disorders · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer A Smith *Diabetes Center, University of California San Francisco, San Francisco, CA 94143.
Benjamin T K Yuen *Diabetes Center, University of California San Francisco, San Francisco, CA 94143.
Whitney PurthaDiabetes Center, University of California San Francisco, San Francisco, CA 94143.
Jared M BalolongDiabetes Center, University of California San Francisco, San Francisco, CA 94143.ORCID 0000-0003-4119-2822
Jonah D PhippsDiabetes Center, University of California San Francisco, San Francisco, CA 94143.ORCID 0000-0001-9685-741X
Frances CrawfordDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206.
Jeffrey A BluestoneSean N. Parker Autoimmune Research Laboratory, Diabetes Center, University of California, San Francisco, CA 94143.
John W KapplerDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206.ORCID 0000-0002-5827-6240
Mark S AndersonDiabetes Center, University of California San Francisco, San Francisco, CA 94143.

Funding

Project 3: Epitope Selection in Type 1 DiabetesP01AI118688 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 2016 to 2020
$8.4M
Tuning peptide specifities for T cell tolerance in Type 1 diabetesR01DK133443 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 2022 to 2025
$1.8M
Juvenile Diabetes Research Foundation FellowshipLarry L. Hillblom Foundation Diabetes FellowshipNIAID NIH HHS P01 AI118688NIDDK NIH HHS R01 DK133443
6 · The paper itself

Abstract

Insulin is a central autoantigen in the pathogenesis of T1D, and thymic epithelial cell expression of insulin under the control of the Autoimmune Regulator (

Indexed as

AIRE ProteinInsulinReceptors, Antigen, T-CellThymus GlandAnimalsCD4-Positive T-LymphocytesClone CellsImmune ToleranceMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicTranscription FactorsAIRE ProteinInsulinReceptors, Antigen, T-CellTranscription FactorsAireantigen-specificinsulinT cell selectionthymic selection

Identifiers

PMID38709934
PMCPMC11098115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.