Evidence map›Paper›PMID 38709926›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A finely balanced order-disorder equilibrium sculpts the folding-binding landscape of an antibiotic sequestering protein.

Lawanya Natarajan, Maria Laura De Sciscio, Alessandro Nicola Nardi, Ashok Sekhar, Alessandra Del Giudice, Marco D'Abramo, Athi N Naganathan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lawanya NatarajanDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.ORCID 0000-0002-9838-2080
Maria Laura De SciscioDepartment of Chemistry, Sapienza University of Rome, Rome 00185, Italy.ORCID 0000-0001-5523-0987
Alessandro Nicola NardiDepartment of Chemistry, Sapienza University of Rome, Rome 00185, Italy.ORCID 0000-0002-0959-1690
Ashok SekharMolecular Biophysics Unit, Indian Institute of Science Bangalore, Bengaluru 560 012, India.
Alessandra Del GiudiceDepartment of Chemistry, Sapienza University of Rome, Rome 00185, Italy.ORCID 0000-0002-1916-8300
Marco D'AbramoDepartment of Chemistry, Sapienza University of Rome, Rome 00185, Italy.ORCID 0000-0001-6020-8581
Athi N NaganathanDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.ORCID 0000-0002-1655-7802

Funding

DST | Science and Engineering Research Board (SERB) CRG/2019/000084DST | Science and Engineering Research Board (SERB) CRG/2019/003457European Synchrotron Radiation Facility (ESRF) MX2464Ministry of Education, India (MoE) 11/9/2019-U.3(A)Wellcome TrustWellcome Trust DBT India Alliance (India Alliance) IA/I/18/1/503614
6 · The paper itself

Abstract

TipA, a MerR family transcription factor from

Indexed as

Anti-Bacterial AgentsBacterial ProteinsProtein FoldingModels, MolecularProtein BindingProtein ConformationStreptomyces lividansTranscription FactorsAnti-Bacterial AgentsBacterial ProteinsTranscription Factorsantibiotic bindingdisorderdynamicsfolding–functionthermodynamics

Identifiers

PMID38709926
PMCPMC11098121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.