Evidence map›Paper›PMID 38709877›Full record

ArticleNucleic acids research2024

IsoVis - a webserver for visualization and annotation of alternative RNA isoforms.

Ching Yin Wan, Jack Davis, Manveer Chauhan, Josie Gleeson, Yair D J Prawer, Ricardo De Paoli-Iseppi, Christine A Wells, Jarny Choi, Michael B Clark

Abstract read
In one paragraph

Article in Nucleic acids research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Isoform-level profiling of mScience advances · 2025
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ching Yin WanDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia.
Jack DavisDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia.
Manveer ChauhanDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia.
Josie GleesonDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0002-4302-9191
Yair D J PrawerDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0002-4446-0733
Ricardo De Paoli-IseppiDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0001-7724-9144
Christine A WellsDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0003-3133-3628
Jarny ChoiDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia.
Michael B ClarkDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID 0000-0002-2903-9537

Funding

National Health and Medical Research Council GNT1196841
6 · The paper itself

Abstract

Genes commonly express multiple RNA products (RNA isoforms), which differ in exonic content and can have different functions. Making sense of the plethora of known and novel RNA isoforms being identified by transcriptomic approaches requires a user-friendly way to visualize gene isoforms and how they differ in exonic content, expression levels and potential functions. Here we introduce IsoVis, a freely available webserver that accepts user-supplied transcriptomic data and visualizes the expressed isoforms in a clear, intuitive manner. IsoVis contains numerous features, including the ability to visualize all RNA isoforms of a gene and their expression levels; the annotation of known isoforms from external databases; mapping of protein domains and features to exons, allowing changes to protein sequence and function between isoforms to be established; and extensive species compatibility. Datasets visualised on IsoVis remain private to the user, allowing analysis of sensitive data. IsoVis visualisations can be downloaded to create publication-ready figures. The IsoVis webserver enables researchers to perform isoform analyses without requiring programming skills, is free to use, and available at https://isomix.org/isovis/.

Indexed as

InternetMolecular Sequence AnnotationRNA IsoformsSoftwareAlternative SplicingAnimalsExonsHumansTranscriptomeRNA Isoforms

Identifiers

PMID38709877
PMCPMC11223830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.