Evidence map›Paper›PMID 38709450›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2024

Influence of UGT2B7, UGT1A4 and ABCG2 Polymorphisms on the Pharmacokinetics and Therapeutic Efficacy of Lamotrigine in Patients with Epilepsy.

Jing Yang, Jinxingyi Wang, Lijie Ning, Changsong Wu, Yang Liu, Jie Xia, Yanping Guan, Qian Liu, Jianghuan Zheng

Abstract read
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In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jing Yang *Department of Neurology, The Second Affiliated Hospital of Guizhou Medical University, Kaili, 556000, Guizhou, China.
Jinxingyi Wang *Department of Pharmacy, The Second Affiliated Hospital of Guizhou Medical University, Kaili, 556000, Guizhou, China.
Lijie Ning *Department of Neurology, The Second Affiliated Hospital of Guizhou Medical University, Kaili, 556000, Guizhou, China.
Changsong WuDepartment of Neurology, The Second Affiliated Hospital of Guizhou Medical University, Kaili, 556000, Guizhou, China.
Yang LiuDepartment of Pharmacy, The Second Affiliated Hospital of Guizhou Medical University, Kaili, 556000, Guizhou, China.
Jie XiaDepartment of Pharmacy, The Second Affiliated Hospital of Guizhou Medical University, Kaili, 556000, Guizhou, China.
Yanping Guan *Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. guanyp3@mail2.sysu.edu.cn.
Qian Liu *Department of Pharmacy, The Second Affiliated Hospital of Guizhou Medical University, Kaili, 556000, Guizhou, China. qian159158@163.com.
Jianghuan Zheng *Department of Neurology, The Second Affiliated Hospital of Guizhou Medical University, Kaili, 556000, Guizhou, China. 1418528797@qq.com.

Funding

Science and Technology Program of Guizhou Province No: KH 2021-12the Science and Technology Project of Guizhou province No: ZK [2022] General 410the Science and Technology Project of Qiandongnan Prefecture 2024the Science and Technology Project of Qiandongnan Prefecture No. 58
6 · The paper itself

Abstract

BACKGROUND AND

objectivesA substantial inter-individual variability has been observed in the pharmacokinetics of lamotrigine. The aim of the study was to investigate the impact of genetic polymorphism of the metabolizing enzymes (UGT2B7, UGT1A4) and transporter (ABCG2) on the pharmacokinetics and therapeutic efficacy of lamotrigine in patients with epilepsy.

methodsThe genetic analysis of single-nucleotide polymorphisms was conducted using polymerase chain reaction sequence. High-performance liquid chromatography/tandem mass spectrometry was employed to measure the plasma concentrations of lamotrigine. The efficacy of lamotrigine was assessed by evaluating the reduction rate of epileptic seizure frequency.

resultsThis study included a cohort of 331 patients who were treated with lamotrigine as monotherapy. A linear correlation was observed between the lamotrigine concentration and daily dose taken (r = 0.58, p < 2.2e

conclusionsUGT1A4 rs2011425 and ABCG2 rs2231142 were correlated with lamotrigine concentrations. Lower lamotrigine trough concentration was found in the ineffective group and the troughs were associated with seizure outcomes.

Indexed as

AnticonvulsantsATP Binding Cassette Transporter, Subfamily G, Member 2EpilepsyGlucuronosyltransferaseLamotrigineNeoplasm ProteinsPolymorphism, Single NucleotideAdolescentAdultAgedChildCohort StudiesFemaleHumansMaleMiddle AgedABCG2 protein, humanAnticonvulsantsATP Binding Cassette Transporter, Subfamily G, Member 2bilirubin glucuronoside glucuronosyltransferaseGlucuronosyltransferaseLamotrigineNeoplasm ProteinsUGT2B7 protein, human

Identifiers

PMID38709450

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