Evidence map›Paper›PMID 38709399›Full record

ReviewMikrochimica acta2024

Emerging biosensor probes for glycated hemoglobin (HbA1c) detection.

Yang Su, Chengen Xia, He Zhang, Wei Gan, Guo-Qi Zhang, Zi Yang, Dapeng Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang SuKey Laboratory of DrugTargeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Chengen XiaKey Laboratory of DrugTargeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
He ZhangDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
Wei GanDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
Guo-Qi ZhangDepartment of Chemistry, School of Science, Xihua University, Chengdu, 610039, People's Republic of China.
Zi YangKey Laboratory of DrugTargeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
Dapeng LiKey Laboratory of DrugTargeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China. dpli@scu.edu.cn.ORCID http://orcid.org/0000-0003-1015-4700

Funding

Natural Science Foundation of Sichuan Province Grant No. 2023NSFSC1673The Innovation Guidance Foundation of the Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Grant No. SCU2023D005The Scientific Research Staring Foundation of Sichuan University Grant No. YJ202165The Young Scientists Fund of the National Natural Science Foundation of China Grant No. 82204513
6 · The paper itself

Abstract

Glycated hemoglobin (HbA1c), originating from the non-enzymatic glycosylation of βVal1 residues in hemoglobin (Hb), is an essential biomarker indicating average blood glucose levels over a period of 2 to 3 months without external environmental disturbances, thereby serving as the gold standard in the management of diabetes instead of blood glucose testing. The emergence of HbA1c biosensors presents affordable, readily available options for glycemic monitoring, offering significant benefits to small-scale laboratories and clinics. Utilizing nanomaterials coupled with high-specificity probes as integral components for recognition, labeling, and signal transduction, these sensors demonstrate exceptional sensitivity and selectivity in HbA1c detection. This review mainly focuses on the emerging probes and strategies integral to HbA1c sensor development. We discussed the advantages and limitations of various probes in sensor construction as well as recent advances in diverse sensing strategies for HbA1c measurement and their potential clinical applications, highlighting the critical gaps in current technologies and future needs in this evolving field.

Indexed as

Biosensing TechniquesGlycated HemoglobinBlood GlucoseDiabetes MellitusHumansBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanBiosensorGlycated hemoglobinHbA1cNanomaterials

Identifiers

PMID38709399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.