ArticleCritical care explorations2024
Preexisting Diabetes Mellitus and All-Cause Mortality in Adult Patients With Sepsis: A Population-Based Cohort Study.
Article in Critical care explorations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diabetes mellitus and mortality in patients admitted to ICU with sepsis: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Clinical Profiles, Interventions, and Outcomes of Sepsis and Septic Shock in a Saudi Arabian Tertiary ICU: A Five-Year Retrospective Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis.Nature communications · 2026Article
- C-reactive protein-triglyceride glucose index and controlling nutritional status score for predicting severe sepsis or septic shock in diabetic patients withFrontiers in endocrinology · 2026Article
- Prior Use of Renin-Angiotensin System Inhibitors and Risk of Renal Replacement Therapy in Critically Ill Elderly Patients With Sepsis: A Population-Based Cohort Study.Critical care explorations · 2025Article
- Analysis of the correlation between the group-based trajectory modeling of serum osmolality and prognosis in patients with sepsis-associated encephalopathy at 72 h after admission.BMC infectious diseases · 2025Article
- The Effect of Ozone on Kidney and Liver Tissues in the Treatment of Sepsis Caused by Cecal Perforation in Diabetic Mice.Drug design, development and therapy · 2025Article
- Impact of Non-Alcoholic Fatty Liver Disease on Sepsis Inpatient Outcomes: A Nationwide Sample Analysis (2000-2019).Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesWe assessed the association of preexisting diabetes mellitus with all-cause mortality and organ support receipt in adult patients with sepsis.
designPopulation-based cohort study.
settingOntario, Canada (2008-2019). POPULATION: Adult patients (18 yr old or older) with a first sepsis-related hospitalization episode.
interventionsNone. MEASUREMENTS AND MAIN
resultsThe main exposure of interest was preexisting diabetes (either type 1 or 2). The primary outcome was all-cause mortality by 90 days; secondary outcomes included receipt of invasive mechanical ventilation and new renal replacement therapy. We report adjusted (for baseline characteristics using standardization) risk ratios (RRs) alongside 95% CIs. A main secondary analysis evaluated the potential mediation by prior metformin use of the association between preexisting diabetes and all-cause mortality following sepsis. Overall, 503,455 adults with a first sepsis-related hospitalization episode were included; 36% had preexisting diabetes. Mean age was 73 years, and 54% of the cohort were females. Preexisting diabetes was associated with a lower adjusted risk of all-cause mortality at 90 days (RR, 0.81; 95% CI, 0.80-0.82). Preexisting diabetes was associated with an increased risk of new renal replacement therapy (RR, 1.53; 95% CI, 1.46-1.60) but not invasive mechanical ventilation (RR, 1.03; 95% CI, 1.00-1.05). Overall, 21% (95% CI, 19-28) of the association between preexisting diabetes and reduced risk of all-cause mortality was mediated by prior metformin use.
conclusionsPreexisting diabetes is associated with a lower risk of all-cause mortality and higher risk of new renal replacement therapy among adult patients with sepsis. Future studies should evaluate the underlying mechanisms of these associations.
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