Evidence map›Paper›PMID 38708951›Full record

ArticleJournal of magnetic resonance imaging : JMRI2025

Dynamic Regularized Adaptive Cluster Optimization (DRACO) for Quantitative Cardiac Cine MRI in Complex Arrhythmias.

Zhengyang Ming, Arutyun Pogosyan, Anthony G Christodoulou, J Paul Finn, Dan Ruan, Kim-Lien Nguyen

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhengyang MingPhysics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.
Arutyun PogosyanDivision of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Anthony G ChristodoulouDepartment of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-9334-8684
J Paul FinnPhysics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.
Dan RuanPhysics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.
Kim-Lien NguyenPhysics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8854-2976

Funding

Expanding on a new paradigm for MRI in pediatric congenital heart diseaseR01HL127153 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTODOULOU, ANTHONY G, FINN, JOHN PAUL · 2015 to 2024
$6.1M
Ferumoxytol-Enhanced Cardiac MRI for Ischemic Heart DiseaseR01HL148182 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NGUYEN, KIM-LIEN T · 2020 to 2024
$3.8M
CSRD VA I01 CX001901NHLBI NIH HHS R01 HL127153NHLBI NIH HHS R01 HL148182NIH HHS R01HL127153NIH HHS R01HL148182Veterans Health Administration Clinical Research and Development I01CX001901
6 · The paper itself

Abstract

backgroundIrregular cardiac motion can render conventional segmented cine MRI nondiagnostic. Clustering has been proposed for cardiac motion binning and may be optimized for complex arrhythmias. PURPOSE: To develop an adaptive cluster optimization method for irregular cardiac motion, and to generate the corresponding time-resolved cine images. STUDY TYPE: Prospective. SUBJECTS: Thirteen with atrial fibrillation, four with premature ventricular contractions, and one patient in sinus rhythm. FIELD STRENGTH/SEQUENCE: Free-running balanced steady state free precession (bSSFP) with sorted golden-step, reference real-time sequence. ASSESSMENT: Each subject underwent both the sorted golden-step bSSFP and the reference Cartesian real-time imaging. Golden-step bSSFP images were reconstructed using the dynamic regularized adaptive cluster optimization (DRACO) method and k-means clustering. Image quality (4-point Likert scale), signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), edge sharpness, and ventricular function were assessed. STATISTICAL TESTS: Paired t-tests, Friedman test, regression analysis, Fleiss' Kappa, Bland-Altman analysis. Significance level P < 0.05.

resultsThe DRACO method had the highest percent of images with scores ≥3 (96% for diastolic frame, 93% for systolic frame, and 93% for multiphase cine) and the percentages were significantly higher compared with both the k-means and real-time methods. Image quality scores, SNR, and CNR were significantly different between DRACO vs. k-means and between DRACO vs. real-time. Cardiac function analysis showed no significant differences between DRACO vs. the reference real-time.

conclusionDRACO with time-resolved reconstruction generated high quality images and has early promise for quantitative cine cardiac MRI in patients with complex arrhythmias including atrial fibrillation. LEVEL OF EVIDENCE: 1: TECHNICAL EFFICACY: Stage 2.

Indexed as

AlgorithmsArrhythmias, CardiacMagnetic Resonance Imaging, CineAdultAgedAtrial FibrillationCluster AnalysisFemaleHeartHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMaleMiddle AgedProspective StudiesReproducibility of Resultsarrhythmiaatrial fibrillationclustering algorithmgolden‐step acquisitionquantitative MRItotal variation

Identifiers

PMID38708951
PMCPMC11538382

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.