SynthesisCNS spectrums2024
Abnormal neural activation during negative emotion processing in anxiety disorders: a coordinate-based meta-analysis.
Synthesis in CNS spectrums, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Judgment behaviors differentiate depression from anxiety.Scientific reports · 2026Article
- Article
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9 authors.
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Abstract
backgroundAnxiety disorders are associated with aberrant neural responses to negative emotions. Yet, the diverse range of contrasts and stimuli used to investigate these responses has produced variable, complex, and sometimes conflicting results.
methodsTo characterize brain activation during negative emotion processing in anxiety disorders, we conducted a meta-analysis of studies contrasting activation to negative stimuli
resultsAcross 20 studies, patients with anxiety disorders (n = 348) had increased activation in core cortical regions of default mode and frontal-parietal networks during negative emotion processing compared to healthy controls (n = 335). Further, differential and greater regional activation was found during the processing of negative scenes than faces and greater activation was associated with sex and age of patients across studies.
conclusionsThese results highlight the importance of self-reference- and cognitive regulation-related functional disturbances in the cortex rather than emotional response-related subcortical alteration during negative emotion processing and indicate a more robust effect from emotional scenes in anxiety disorders.
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