ReviewBJPsych open2024
Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis.
Review in BJPsych open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical and Sociodemographic Correlates of Poor Medication Adherence in People With Bipolar Disorder: A Systematic Review and Meta-Analysis.Bipolar disorders · 2026Pooled it
- Complete blood count-based inflammatory ratios in people with bipolar disorder: a systematic review and meta-analysis of neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios.European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- A preliminary cross-sectional study of bipolarity and primary pharmacotherapy in long-term stable patients with major depressive disorder.International journal of bipolar disorders · 2026Article
- Expert Consensus on the Use of Lurasidone for Bipolar I Depression in Asian Patients.Alpha psychiatry · 2026Article
- Docosahexaenoic acid modulates myo-inositol and myo-inositol biosynthetic genes expression: implications for bipolar disorder.Pharmacological reports : PR · 2026Article
- Trends in bipolar disorder-related mortality in the United States, 1999-2023: A CDC WONDER database analysis.International journal of bipolar disorders · 2026Article
- Predominant polarity as a potential moderator of group CBT outcomes in bipolar disorder: an exploratoryFrontiers in psychiatry · 2026Article
- Differentiating Between Major Depressive Disorder and Bipolar Disorder.Advances in experimental medicine and biology · 2026Review
- The Promise of Long-acting Injectable Antipsychotics for the Treatment of Bipolar I Disorder: The Role of Manic Predominance.Actas espanolas de psiquiatria · 2025Article
- The role of predominant polarity in older age bipolar disorder.International journal of bipolar disorders · 2025Article
- Bipolar disorder.Lancet (London, England) · 2025Review
- Clinical prescription of lithium, anticonvulsants antipsychotics, and antidepressants for major mood disorders.International journal of bipolar disorders · 2025Article
- Factors associated with the frequency of manic and depressive episodes in bipolar disorder: a multicenter study in China.BMC psychiatry · 2025Article
- Predominant Polarity for Enhanced Phenotyping and Personalized Treatment of Bipolar Disorder: A Narrative Review on Recent Findings.Current psychiatry reports · 2025Review
- Exploring the predictive role of the first mood episode on the predominant polarity in bipolar disorder: insights from a path analysis.Annals of general psychiatry · 2025Article
- The effect of depression on non-suicidal self-injury and psychological status in adolescents with unipolar and bipolar disorders.BMC psychology · 2024Article
- The role of predominant polarity on cognitive dysfunctions in patients with bipolar disorder.International journal of bipolar disorders · 2024Article
- Combining predominant polarity and affective spectrum concepts in bipolar disorder: towards a novel theoretical and clinical perspective.International journal of bipolar disorders · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentification of the predominant polarity, i.e. hypomanic/manic (mPP) or depressive predominant polarity (dPP), might help clinicians to improve personalised management of bipolar disorder.
aimsWe performed a systematic review and meta-analysis to estimate prevalence and correlates of mPP and dPP in bipolar disorder.
methodThe protocol was registered in the Open Science Framework Registries (https://doi.org/10.17605/OSF.IO/8S2HU). We searched main electronic databases up to December 2023 and performed random-effects meta-analyses of weighted prevalence of mPP and dPP. Odds ratios and weighted mean differences (WMDs) were used for relevant correlates.
resultsWe included 28 studies, providing information on rates and/or correlates of mPP and dPP. We estimated similar rates of mPP (weighted prevalence = 30.0%, 95% CI: 23.1 to 37.4%) and dPP (weighted prevalence = 28.5%, 95% CI: 23.7 to 33.7%) in bipolar disorder. Younger age (WMD = -3.19, 95% CI: -5.30 to -1.08 years), male gender (odds ratio = 1.39, 95% CI: 1.10 to 1.76), bipolar-I disorder (odds ratio = 4.82, 95% CI: 2.27 to 10.24), psychotic features (odds ratio = 1.56, 95% CI: 1.01 to 2.41), earlier onset (WMD = -1.57, 95% CI: -2.88 to -0.26 years) and manic onset (odds ratio = 13.54, 95% CI: 5.83 to 31.46) were associated with mPP (
conclusionsDespite some limitations, our findings support the hypothesis that predominant polarity might be a useful specifier of bipolar disorder. Evidence quality was mixed, considering effects magnitude, consistency, precision and publication bias. Different predominant polarities may identify subgroups of patients with specific clinical characteristics.
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