Evidence map›Paper›PMID 38708544›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2024

Pregnancy-induced oxidative stress and inflammation are not associated with impaired maternal neuronal activity or memory function.

Jessica L Bradshaw, E Nicole Wilson, Jennifer J Gardner, Steve Mabry, Selina M Tucker, Nataliya Rybalchenko, Edward Vera, Styliani Goulopoulou, Rebecca L Cunningham

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jessica L BradshawDepartment of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0003-4011-8401
E Nicole WilsonDepartment of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Jennifer J GardnerDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Steve MabryDepartment of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Selina M TuckerDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0002-7959-8716
Nataliya RybalchenkoDepartment of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Edward VeraTexas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Styliani GoulopoulouLawrence D. Longo Center for Perinatal Biology, Departments of Basic Sciences, Gynecology and Obstetrics, Loma Linda University, Loma Linda, California, United States.ORCID 0000-0001-7636-8256
Rebecca L CunninghamDepartment of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0001-5984-5516

Funding

Training in the Neurobiology of Aging and Alzheimer's DiseaseT32AG020494 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROBERT Clinton BARBER, NATHALIE SUMIEN · 2002 to 2026
$6.9M
Preeclampsia and pre-clinical stages of maternal vascular dementiaR01HL146562 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI GOULOPOULOU, STYLIANI · 2020 to 2024
$2.9M
American Heart Association (AHA) 1012811American Heart Association (AHA) 900431American Heart Association (AHA) 903250HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL146562HHS | NIH | National Institute on Aging (NIA) AG020494NHLBI NIH HHS R01 HL146562NIA NIH HHS T32 AG020494
6 · The paper itself

Abstract

Pregnancy is associated with neural and behavioral plasticity, systemic inflammation, and oxidative stress, yet the impact of inflammation and oxidative stress on maternal neural and behavioral plasticity during pregnancy is unclear. We hypothesized that healthy pregnancy transiently reduces learning and memory and these deficits are associated with pregnancy-induced elevations in inflammation and oxidative stress. Cognitive performance was tested with novel object recognition (recollective memory), Morris water maze (spatial memory), and open field (anxiety-like) behavior tasks in female Sprague-Dawley rats of varying reproductive states [nonpregnant (nulliparous), pregnant (near term), and 1-2 mo after pregnancy (primiparous);

Indexed as

Oxidative StressRats, Sprague-DawleyAnimalsAnxietyCA1 Region, HippocampalCytokinesFemaleInflammationInflammation MediatorsMaze LearningMemoryNeuronsPregnancyRatsSpatial MemoryCytokinesInflammation Mediatorsanxiety-like behaviorcognitioninflammationoxidative stressparity

Identifiers

PMID38708544
PMCPMC11381002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.