Evidence map›Paper›PMID 38708511›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Upregulating KLF11 ameliorates intestinal inflammation in mice with 2, 4, 6-trinitrobenesulfonic acid-induced colitis by inhibiting the JAK2/STAT3 signaling pathway].

J Xi, M Zhang, Y Zhang, C Zhang, Y Zhang, R Wang, L Shen, J Li, X Song

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Therapeutic mechanism ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J XiBengbu Medical University, Bengbu 233000, China.
M ZhangBengbu Medical University, Bengbu 233000, China.
Y ZhangBengbu Medical University, Bengbu 233000, China.
C ZhangBengbu Medical University, Bengbu 233000, China.
Y ZhangBengbu Medical University, Bengbu 233000, China.
R WangBengbu Medical University, Bengbu 233000, China.
L ShenBengbu Medical University, Bengbu 233000, China.
J LiClinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
X SongCentral Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression level of Kruppel-like transcription factor family member KLF11 in intestinal mucosal tissues of Crohn's disease (CD) and its regulatory effect on intestinal inflammation in CD-like colitis.

methodsWe examined KLF11 expression levels in diseased and normal colon mucosal tissues from 12 CD patients and 12 patients with colorectal cancer using immunofluorescence staining. KLF11 expression was also detected in the colon mucosal tissues of a mouse model of 2, 4, 6-trinitrobenesulfonic acid (TNBS)-induced colitis. A recombinant adenoviral vector was used to upregulate KLF11 expression in the mouse models and the changes in intestinal inflammation was observed. A Caco-2 cell model with stable KLF11 overexpression was constructed by lentiviral infection. The effect of KLF11 overexpression on expressions of JAK2/STAT3 signaling pathway proteins was investigated using immunoblotting in both the mouse and cell models. The mouse models were treated with coumermycin A1, a JAK2/STAT3 signaling pathway agonist, and the changes in intestinal inflammatory responses were observed.

resultsThe expression level of KLF11 was significantly lowered in both the clinical specimens of diseased colon mucosal tissues and the colon tissues of mice with TNBS-induced colitis (

conclusionKLF11 is downregulated in the intestinal mucosa in CD, and upregulation of KLF11 can improve intestinal inflammation and reduce the production of inflammatory factors probably by inhibiting the JAK2/STAT3 signaling pathway.

Indexed as

ColitisIntestinal MucosaJanus Kinase 2Repressor ProteinsSignal TransductionAnimalsApoptosis Regulatory ProteinsCaco-2 CellsCrohn DiseaseDisease Models, AnimalHumansInflammationMiceSTAT3 Transcription FactorTranscription FactorsTrinitrobenzenesulfonic AcidApoptosis Regulatory ProteinsJAK2 protein, humanJanus Kinase 2KLF11 protein, humanRepressor ProteinsSTAT3 Transcription FactorTranscription FactorsTrinitrobenzenesulfonic AcidCrohn's diseaseintestinal inflammationJAK2/STAT3KLF11

Identifiers

PMID38708511
PMCPMC11073944

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.