Evidence map›Paper›PMID 38708505›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[α2-macroglobulin alleviates glucocorticoid-induced avascular necrosis of the femoral head in mice by promoting proliferation, migration and angiogenesis of vascular endothelial cells].

Q Zhu, Y Lu, Y Peng, J He, Z Wei, Z Li, Y Chen

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Q ZhuDepartment of Joint Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China.
Y LuDepartment of Joint Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China.
Y PengDepartment of Joint Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China.
J HeDepartment of Joint Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China.
Z WeiDepartment of Joint Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China.
Z LiDepartment of Joint Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China.
Y ChenDepartment of Joint Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the mechanism underlying the protective effect of α2-macroglobulin (A2M) against glucocorticoid-induced femoral head necrosis.

methodsIn a human umbilical vein endothelial cell (HUVEC) model with injuries induced by gradient concentrations of dexamethasone (DEX; 10

resultsIn cultured HUVECs, DEX treatment significantly reduced cell viability, migration and angiogenic ability in a concentration- and time-dependent manner (

conclusionA2M promotes proliferation, migration, and angiogenesis of DEX-treated HUVECs and alleviates methylprednisolone-induced femoral head necrosis by improving microcirculation damages and maintaining microcirculation stability in the femoral head.

Indexed as

DexamethasoneFemur Head NecrosisGlucocorticoidsAngiogenesisAnimalsCell MovementCell ProliferationCell SurvivalFemur HeadHumansHuman Umbilical Vein Endothelial CellsMiceMice, Inbred BALB CPlatelet Endothelial Cell Adhesion Molecule-1Vascular Endothelial Growth Factor ADexamethasoneGlucocorticoidsPlatelet Endothelial Cell Adhesion Molecule-1Vascular Endothelial Growth Factor Aendothelial dysfunctionsteroid-induced avascular necrosis of the femoral headvascular endothelial growth factor-Aα2-macroglobulin

Identifiers

PMID38708505
PMCPMC11073947

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.