Evidence map›Paper›PMID 38708503›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Zinc finger protein-36 deficiency inhibits osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells and preosteoblasts by activating the ERK/MAPK pathway].

S Rong, H Li, Y Wei, Z Feng, L Gan, Z Deng, L Zhao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S RongDepartment of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
H LiBeijing Yijiandian Clinic, Beijing 100033, China.
Y WeiDepartment of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Z FengDepartment of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
L GanDepartment of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Z DengDepartment of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
L ZhaoDepartment of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the role of zinc finger protein 36(ZFP36) in regulating osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) and preosteoblasts.

methodsZFP36 expression was observed in primary mouse BMSCs and mouse preosteoblasts (MC3T3-E1 cells) during induced osteogenic differentiation.

resultsDuring the 14-day induction of osteogenic differentiation, both mouse BMSCs and MC3T3-E1 cells exhibited increased expression of ZFP36, and its mRNA expression reached the peak level on Day 7(

conclusionsZFP36 is involved in the regulation of osteoblast differentiation of mouse BMSCs and preosteoblasts, and ZFP36 deficiency causes inhibition of osteoblast differentiation of the cells by activating the ERK/MAPK signaling pathway.

Indexed as

Cell DifferentiationMAP Kinase Signaling SystemMesenchymal Stem CellsOsteoblastsOsteogenesisAlkaline PhosphataseAnimalsBone Marrow CellsButyrate Response Factor 1MiceTristetraprolinAlkaline PhosphataseButyrate Response Factor 1TristetraprolinZfp36 protein, mousebonemarrow-derived mesenchymal stem cellsERK/MAPK signaling pathwayosteoblast differentiationzinc finger protein 36

Identifiers

PMID38708503
PMCPMC11073938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.