Evidence map›Paper›PMID 38708500›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Exercise promotes irisin expression to ameliorate renal injury in type 2 diabetic rats].

F Zhou, Y Guo, N Chen

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

F ZhouCollege of Sport Medicine, Wuhan Sports University, Wuhan 430079, China.
Y GuoCollege of Sport Medicine, Wuhan Sports University, Wuhan 430079, China.
N ChenCollege of Sport Medicine, Wuhan Sports University, Wuhan 430079, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the role of irisin in exercise-induced improvement of renal function in type 2 diabetic rats.

methodsForty male SD rats aged 4-6 weeks were randomized into normal control group, type 2 diabetes mellitus model group, diabetic exercise (DE) group and diabetic irisin (DI) group (

resultsThe diabetic rats showed significantly increased levels of fasting insulin, total cholesterol, triglyceride, serum creatinine and blood urea nitrogen with lowered serum irisin level (all

conclusionBoth exercise and exogenous irisin treatment improve nephropathy in type 2 diabetic rats possibly due to irisin-mediated activation of the AMPK/SIRT1 pathway in the kidneys to promote renal autophagy.

Indexed as

AutophagyDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FibronectinsKidneyPhysical Conditioning, AnimalRats, Sprague-DawleySirtuin 1AMP-Activated Protein KinasesAnimalsBeclin-1Blood Urea NitrogenCholesterolCreatinineDiabetic NephropathiesInsulinAMP-Activated Protein KinasesBeclin-1CholesterolCreatinineFibronectinsFNDC5 protein, ratInsulinSirt1 protein, ratSirtuin 1TriglyceridesAMPK/SIRT1 signaling pathwayautophagyexerciseirisinkidneytype 2 diabetic rat

Identifiers

PMID38708500
PMCPMC11073942

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.