Evidence map›Paper›PMID 38708443›Full record

ReviewCytoskeleton (Hoboken, N.J.)2024

Roles of myosin 1e and the actin cytoskeleton in kidney functions and familial kidney disease.

Pei-Ju Liu, Kazi Sayeeda, Cindy Zhuang, Mira Krendel

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cytoskeleton (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pei-Ju LiuDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York, USA.
Kazi SayeedaDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York, USA.
Cindy ZhuangDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York, USA.
Mira KrendelDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York, USA.ORCID https://orcid.org/0000-0002-7008-9069

Funding

Role of myosin 1e in podocyte biology and renal filtrationR01DK083345 · NIDDK · UPSTATE MEDICAL UNIVERSITY · PI Mira Krendel · 2011 to 2026
$6.8M
NIDDK NIH HHS R01 DK083345NIDDK NIH HHS R01DK083345
6 · The paper itself

Abstract

Mammalian kidneys are responsible for removing metabolic waste and maintaining fluid and electrolyte homeostasis via selective filtration. One of the proteins closely linked to selective renal filtration is myosin 1e (Myo1e), an actin-dependent molecular motor found in the specialized kidney epithelial cells involved in the assembly and maintenance of the renal filter. Point mutations in the gene encoding Myo1e, MYO1E, have been linked to familial kidney disease, and Myo1e knockout in mice leads to the disruption of selective filtration. In this review, we discuss the role of the actin cytoskeleton in renal filtration, the known and hypothesized functions of Myo1e, and the possible explanations for the impact of MYO1E mutations on renal function.

Indexed as

Actin CytoskeletonKidneyKidney DiseasesMyosin Type IAnimalsHumansMiceMYO1E protein, humanMyo1e protein, mouseMyosin Type Iactinendocytosiskidneymyosinpodocyte

Identifiers

PMID38708443
PMCPMC11538376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.