Evidence map›Paper›PMID 38708422›Full record

ArticleBiochemistry and biophysics reports2024

EGCG induces degradation of active folate in serum via H

Guangbin Zhou, Mengmeng Zhang, Xiaoyu Sun, Ting Huang, Kun Hou, Siqi Zhou, Jun Yin, Liping Guan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guangbin ZhouSchool of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Mengmeng ZhangDalian Boyuan Medical Technology Co., Ltd, Dalian, 116000, China.
Xiaoyu SunDalian Boyuan Medical Technology Co., Ltd, Dalian, 116000, China.
Ting HuangShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China.
Kun HouDalian Boyuan Medical Technology Co., Ltd, Dalian, 116000, China.
Siqi ZhouSchool of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Jun YinSchool of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Liping GuanDalian Boyuan Medical Technology Co., Ltd, Dalian, 116000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Empirical studies have indicated that excessive tea consumption may potentially decrease folate levels within the human body. The main active component in green tea, epigallocatechin gallate (EGCG), significantly reduces the concentration of 5-methyltetrahydrofolate (5-MTHF) in both solution and serum. However, our findings also demonstrate that the pro-degradation effect of EGCG on 5-MTHF can be reversed by L-ascorbic acid (AA). Subsequent investigations suggest that EGCG could potentially expedite the degradation of 5-MTHF by generating hydrogen peroxide. In summary, excessive tea intake may lead to reduced folate levels in the bloodstream, yet timely supplementation of AA could potentially safeguard folate from degradation.

Indexed as

5-methyltetrahydrofolateEpigallocatechin gallateHydrogen peroxideL-ascorbic acidPro-oxidant

Identifiers

PMID38708422
PMCPMC11066525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.