Enzymatically Triggered Peptide-Lipid Conjugation of Designed Membrane Active Peptides for Controlled Liposomal Release.

Alexandra Iversen, Johanna Utterström, Robert Selegård, Daniel Aili

Abstract read

In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandra IversenLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Linköping University, Linköping 581 83, Sweden.ORCID https://orcid.org/0000-0003-4685-0505

Johanna UtterströmLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Linköping University, Linköping 581 83, Sweden.ORCID https://orcid.org/0000-0003-2150-1894

Robert SelegårdLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Linköping University, Linköping 581 83, Sweden.ORCID https://orcid.org/0000-0002-1781-1489

Daniel AiliLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Linköping University, Linköping 581 83, Sweden.ORCID https://orcid.org/0000-0002-7001-9415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Possibilities for controlling the release of pharmaceuticals from liposomal drug delivery systems can enhance their efficacy and reduce their side effects. Membrane-active peptides (MAPs) can be tailored to promote liposomal release when conjugated to lipid head groups using thiol-maleimide chemistry. However, the rapid oxidation of thiols hampers the optimization of such conjugation-dependent release strategies. Here, we demonstrate a

Identifiers

PMID38708287

DOI10.1021/acsomega.4c01387

PMCPMC11064179

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.