Evidence map›Paper›PMID 38708130›Full record

ArticleiRadiology2024

Elevating theranostics: The emergence and promise of radiopharmaceutical cell-targeting heterodimers in human cancers.

Claudia Chambers, Broc Chitwood, Charles J Smith, Yubin Miao

Abstract read
In one paragraph

Article in iRadiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Development ofEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Claudia ChambersMolecular Imaging and Theranostics Center, Columbia, Missouri, USA.ORCID 0009-0003-1138-5751
Broc ChitwoodMolecular Imaging and Theranostics Center, Columbia, Missouri, USA.
Charles J SmithMolecular Imaging and Theranostics Center, Columbia, Missouri, USA.
Yubin MiaoDepartment of Radiology, University of Colorado Denver, Aurora, Colorado, USA.

Funding

Midwest Biomedical Accelerator Consortium: MBArCU01HL152410 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI FAY, WILLIAM P, GRANT, SHEILA ANN · 2019 to 2023
$5.6M
Novel Receptor-Targeting Peptides for Melanoma TherapyR01CA225837 · NCI · UNIVERSITY OF COLORADO DENVER · PI MIAO, YUBIN · 2018 to 2022
$1.9M
Combinations of Receptor-Targeted Alpha Radionuclide Therapy and Immune Checkpoint Inhibitors for Melanoma TreatmentR01CA269221 · NCI · UNIVERSITY OF COLORADO DENVER · PI MIAO, YUBIN · 2023 to 2025
$1.8M
Phage Display for Improved Peptide-Based Tumor Targeting and Imaging AgentsI01BX000964 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI DEUTSCHER, SUSAN L, SMITH, CHARLES J · 2011 to 2025
–
BLRD VA I01 BX000964NCI NIH HHS R01 CA225837NCI NIH HHS R01 CA269221NHLBI NIH HHS U01 HL152410
6 · The paper itself

Abstract

Optimal therapeutic and diagnostic efficacy is essential for healthcare's global mission of advancing oncologic drug development. Accurate diagnosis and detection are crucial prerequisites for effective risk stratification and personalized patient care in clinical oncology. A paradigm shift is emerging with the promise of multi-receptor-targeting compounds. While existing detection and staging methods have demonstrated some success, the traditional approach of monotherapy is being reevaluated to enhance therapeutic effectiveness. Heterodimeric site-specific agents are a versatile solution by targeting two distinct biomarkers with a single theranostic agent. This review describes the innovation of dual-targeting compounds, examining their design strategies, therapeutic implications, and the promising path they present for addressing complex diseases.

Indexed as

GRPRheterobivalentheterodimerhybrid peptideMSHPSMASSTαvβ3

Identifiers

PMID38708130
PMCPMC11067702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.