ArticleAdvanced nanobiomed research2023
Silk Fibroin Particles as Carriers in the Development of Hemoglobin-Based Oxygen Carriers.
Article in Advanced nanobiomed research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Multimodal characterization of temperature-induced structural remodeling and aggregation of regenerated silk fibroin.RSC advances · 2026Article
- Protein Sequence and Structural Diversity inBiomacromolecules · 2026Article
- Sodium Dodecylbenzene Sulfonate-Mediated Self-Assembly of Silk Particles from Formic Acid Solutions into Robust Films.Polymers · 2025Article
- Silk Fibroin Particle-Laden Sponges as a Multiphase Controlled Release Platform.Regenerative engineering and translational medicine · 2025Article
- Degumming Time Governs Self-Assembled Silk Fibroin Hydrogel Properties through Molecular Weight and Amino Acid Composition.Biomacromolecules · 2025Article
- Self-Assembly ofIndustrial & engineering chemistry research · 2025Article
- Exploring the functional properties ofMaterials today. Communications · 2025Article
- Comparative Evaluation of UV-Vis Spectroscopy-Based Approaches for Hemoglobin Quantification: Method Selection and Practical Insights.Biomolecules · 2024Article
- Harvesting Silk Fibers fromACS biomaterials science & engineering · 2024Article
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8 authors.
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Abstract
Oxygen therapeutics have a range of applications in transfusion medicine and disease treatment. Synthetic molecules and all-natural or semi-synthetic hemoglobin-based oxygen carriers (HBOCs) have seen success as potential circulating oxygen carriers. However, many early HBOC products stalled in development due to side effects from excess hemoglobin in the blood stream and hemoglobin entering the tissue. To overcome these issues, research has focused on increasing the molecular diameter of hemoglobin by polymerizing hemoglobin molecules or encapsulating hemoglobin in liposomal carriers. This work leverages the properties of silk fibroin, a cytocompatible and non-thrombogenic biopolymer, known to entrap protein-based cargo, to engineer a fully protein-based oxygen carrier. Herein, an all-aqueous solvent evaporation technique was used to form silk particles via phase separation from a bulk polyvinyl alcohol phase (PVA). Particles size was tuned, and particles were formed with and without hemoglobin. The encapsulation efficiency and ferrous state of hemoglobin were analyzed, resulting in 60% encapsulation efficiency and a maximum of 20% ferric hemoglobin, yielding 100 µg/mL active hemoglobin in certain sfHBOC formulations. The system did not elicit a strong inflammation response
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Registered trials
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