Evidence map›Paper›PMID 38707998›Full record

ArticleClinical & translational immunology2024

Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque.

Xaquin Castro Dopico, Mariia Guryleva, Marco Mandolesi, Martin Corcoran, Jonathan M Coquet, Ben Murrell, Gunilla B Karlsson Hedestam

Abstract read
In one paragraph

Article in Clinical & translational immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xaquin Castro DopicoDepartment of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0002-9005-6774
Mariia GurylevaDepartment of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0009-0004-6370-7510
Marco MandolesiDepartment of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0003-2927-7831
Martin CorcoranDepartment of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0002-2774-0936
Jonathan M CoquetDepartment of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0002-5967-4857
Ben MurrellDepartment of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0002-0393-4445
Gunilla B Karlsson HedestamDepartment of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden.ORCID https://orcid.org/0000-0001-7255-9047

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The caecum bridges the small and large intestine and plays a front-line role in discriminating gastrointestinal antigens. Although dysregulated in acute and chronic conditions, the tissue is often overlooked immunologically. Methods: To address this issue, we applied single-cell transcriptomic-V(D)J sequencing to FACS-isolated CD45 Results: We found caecal NK cells and ILC3s to co-exist with a spectrum of effector T cells partially derived from Conclusions: The data advance our understanding of caecal immunological function, revealing processes involved in barrier maintenance and molecular networks relevant to disease.

Indexed as

caecumgut homeostasisrhesus macaquesingle‐cell RNA sequencingtissue atlas

Identifiers

PMID38707998
PMCPMC11063928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.