Evidence map›Paper›PMID 38707817›Full record

ArticleKidney international reports2024

Characteristics and Outcomes of NELL1 Membranous Nephropathy in Lipoic Acid Users and Nonusers.

Rupali S Avasare, Samantha Clark, Rebecca I Spain, Raghav Wusirika, Robert Rope, Susan Gurley, Madison Stanaway, Miroslav Sekulic, Dominick Santoriello, Andrew S Bomback and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Questions and Caveats in Antigen-Defined Membranous Nephropathy.Journal of the American Society of Nephrology : JASN · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rupali S AvasareDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Samantha ClarkSchool of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Rebecca I SpainDepartment of Neurology, Oregon Health and Science University, Portland, Oregon, USA.
Raghav WusirikaDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Robert RopeDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Susan GurleyDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Madison StanawayDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Miroslav SekulicDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Dominick SantorielloDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Andrew S BombackDivision of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Pietro CanettaDivision of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Sitalakshmi J IyerKidney Care Physicians, LLC, Salem, Oregon, USA.
Vanderlene KungDepartment of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Vivek CharuDepartment of Pathology, Stanford University, Palo Alto, California, USA.
Megan L TroxellDepartment of Pathology, Stanford University, Palo Alto, California, USA.
Satoru KudoseDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Nicole K AndeenDepartment of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, Oregon, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neural epidermal growth factor like 1 membranous nephropathy (NELL1 MN) is associated with various secondary etiologies. However, previous studies on the frequency of these associations and their impact on outcomes are limited. We report a large multiinstitutional series of patients with NELL1 MN with a focus on secondary associations, pathology findings, and their impact on outcome. Methods: We retrospectively reviewed clinicopathologic features of NELL1 MN from 3 institutions and analyzed clinical and histologic associations with outcome. Results: Of 70 patients, 53% were male with a median age of 66 years; median proteinuria was 5.9 g/d. NELL1 MN was associated with lipoic acid (36%), heavy nonsteroidal antiinflammatory drug (NSAID) use (27%), autoimmune disease (23%), malignancy (10% recent, 23% any), mercury exposure (1%), and 11% had no known secondary association. At median follow-up of 11 months, 72% achieved complete or partial remission. Remission rate was 91% in patients with lipoic acid-associated NELL1 MN and ≥6 months of follow-up. On multivariable analyses, patients with primary NELL1 MN (adjusted odds ratio [OR]: 19.7, Conclusion: Our findings strengthen the association between lipoic acid and NELL1 MN. Furthermore, our findings suggest that discontinuation of lipoic acid without immunosuppression should be considered as the first-line treatment.

Indexed as

drug-induced kidney diseaseglomerular diseaselipoic acidmembranous nephropathyNELL1NSAID

Identifiers

PMID38707817
PMCPMC11068956

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.