Evidence map›Paper›PMID 38707508›Full record

ArticleBilingualism (Cambridge, England)2024

Examining the relation between bilingualism and age of symptom onset in frontotemporal dementia.

Jessica de Leon, Stephanie Grasso, Isabel Elaine Allen, Danielle P Escueta, Yvette Vega, Malihe Eshghavi, Christa Watson, Nina Dronkers, Maria Luisa Gorno-Tempini, Maya L Henry

Abstract read
In one paragraph

Article in Bilingualism (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Cognitive and brain reserve in bilingual speakers with clinical AD variants.medRxiv : the preprint server for health sciences · 2026
    Article
  3. The role of bilingualism on functional decline and neurodegeneration in distinct ADRD clinical syndromes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jessica de LeonDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.
Stephanie GrassoDepartment of Speech, Language and Hearing Sciences, University of Texas At Austin, Texas, USA.
Isabel Elaine AllenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
Danielle P EscuetaDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.
Yvette VegaDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.
Malihe EshghaviDepartment of International and Multicultural Education, University of San Francisco, California, USA.
Christa WatsonDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.
Nina DronkersDepartment of Psychology, University of California, Berkeley, California, USA.
Maria Luisa Gorno-TempiniDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA.
Maya L HenryDepartment of Speech, Language and Hearing Sciences, University of Texas At Austin, Texas, USA.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
Word fluency task performance as a marker of Alzheimer’s disease in Tagalog/English bilingual speakerR01AG080396 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jessica Anne Deleon · 2023 to 2026
$3.3M
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR01DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2017 to 2021
$3.3M
Neural Mechanisms of Language Production Decline in Primary Progressive AphasiaR01DC016345 · NIDCD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DRONKERS, NINA F. · 2017 to 2022
$2.8M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Multimodal Imaging in Frontotemporal DegenerationK24AG045333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2013 to 2023
$1.9M
Primary Progressive Aphasia: Beyond the Clinical VariantsK23DC018021 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DELEON, JESSICA ANNE · 2020 to 2024
$995k
Patterns of decline and recovery in bilingual speakers with primary progressive aphasiaF31DC016229 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI GRASSO, STEPHANIE M · 2017 to 2019
$112k
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR56DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2023 to 2023
$97k
NCATS NIH HHS KL2 TR001870NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG080396NIDCD NIH HHS F31 DC016229NIDCD NIH HHS K23 DC018021NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC016291NIDCD NIH HHS R01 DC016345NIDCD NIH HHS R56 DC016291NINDS NIH HHS R01 NS050915NINDS NIH HHS RF1 NS050915
6 · The paper itself

Abstract

Bilingualism is thought to confer advantages in executive functioning, thereby contributing to cognitive reserve and a later age of dementia symptom onset. While the relation between bilingualism and age of onset has been explored in Alzheimer's dementia, there are few studies examining bilingualism as a contributor to cognitive reserve in frontotemporal dementia (FTD). In line with previous findings, we hypothesized that bilinguals with behavioral variant FTD would be older at symptom onset compared to monolinguals, but that no such effect would be found in patients with nonfluent/agrammatic variant primary progressive aphasia (PPA) or semantic variant PPA. Contrary to our hypothesis, we found no significant difference in age at symptom onset between monolingual and bilingual speakers within any of the FTD variants, and there were no notable differences on neuropsychological measures. Overall, our results do not support a protective effect of bilingualism in patients with FTD-spectrum disease in a U.S. based cohort.

Indexed as

Alzheimer’s dementiabilingualismcognitive reservefrontotemporal dementiaprimary progressive aphasia

Identifiers

PMID38707508
PMCPMC11065430

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.