Evidence map›Paper›PMID 38707484›Full record

ArticleClinical neurophysiology practice2024

Compound muscle action potential of whole-forearm flexors: A clinical biomarker for inclusion body myositis.

Tomoo Mano, Naohiko Iguchi, Naoki Iwasa, Nanami Yamada, Kazuma Sugie

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Article in Clinical neurophysiology practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Tomoo ManoDepartment of Neurology, Nara Medical University, Kashihara, Japan.
Naohiko IguchiDepartment of Neurology, Nara Medical University, Kashihara, Japan.
Naoki IwasaDepartment of Neurology, Nara Medical University, Kashihara, Japan.
Nanami YamadaDepartment of Neurology, Nara Medical University, Kashihara, Japan.
Kazuma SugieDepartment of Neurology, Nara Medical University, Kashihara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to investigate the potential of whole-forearm flexor muscle (WFFM) compound muscle action potential (CMAP) as a quantitative biomarker for inclusion body myositis (IBM) pathology. Methods: We prospectively enrolled 14 consecutive patients (10 men and 4 women) diagnosed with IBM based on muscle biopsies. We evaluated the baseline-to-peak amplitude of the WFFM CMAP and other quantitative parameters, including grip and pinch strength, Inclusion Body Myositis Functional Rating Scale (IBMFRS) score, and other routine muscle CMAP amplitudes. Results: The WFFM CMAP was strongly correlated with disease duration and the IBMFRS score. The WFFM CMAP on the more affected side was lower than that on the less affected side. Furthermore, grip power was strongly correlated with the WFFM CMAP, whereas lateral pinch strength was strongly correlated with the WFFM and first dorsal interosseous CMAPs. The 3-point pinch strength was also correlated with the WFFM CMAP. Conclusions: This study demonstrates that the WFFM CMAP may serve as a biomarker of severity in IBM. Significance: Identification of this biomarker can support drug development, diagnosis, prognosis, and treatment options for patients with IBM.

Indexed as

BiomarkerCompound muscle action potentialForearm flexor muscleInclusion body myosisNerve-conduction study

Identifiers

PMID38707484
PMCPMC11066998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.