Evidence map›Paper›PMID 38707453›Full record

ArticleHeliyon2024

Efficient drug delivery potential and antimicrobial activity of biocompatible hydrogels of dextrin/Na-alginate/PVA.

Arif Nazir, Mazhar Abbas, Faiza Kainat, Dure Najaf Iqbal, Farheen Aslam, Abida Kamal, Osama A Mohammed, Kinza Zafar, Amal Abdullah Alrashidi, Samar Z Alshawwa and 1 more

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In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Arif NazirDepartment of Chemistry, The University of Lahore, Lahore, Pakistan.
Mazhar AbbasDepartment of Basic Sciences, University of Veterinary and Animal Sciences, Lahore, (Jhang-Campus), Pakistan.
Faiza KainatDepartment of Chemistry, The University of Lahore, Lahore, Pakistan.
Dure Najaf IqbalDepartment of Chemistry, The University of Lahore, Lahore, Pakistan.
Farheen AslamDepartment of Biotechnology, Lahore College for Women University, Lahore, Pakistan.
Abida KamalDepartment of Chemistry, University of Agriculture, Faisalabad, Pakistan.
Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia.
Kinza ZafarMedical Unit#2, Lahore General Hospital, 54000, Lahore, Pakistan.
Amal Abdullah AlrashidiDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Samar Z AlshawwaDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Munawar IqbalDepartment of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceftriaxone sodium belongs to the third-generation cephalosporin group and is used intramuscular and intravenous route as a broad-spectrum antibiotic. This research aims to prepare biocompatible hydrogels for targeted delivery of ceftriaxone sodium by parental route. Different proportions of polymers (natural and synthetic) in the presence of cross-linker were synthesized by solvent casting method. Ceftriaxone sodium was loaded in hydrogels in different concentrations and its drug release behavior was evaluated along with swelling and biodegradation analysis. The characterization of hydrogel was done by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) to analyze surface morphology and functional groups involved in the formation of dextrin/Na-alginate/PVA hydrogels loaded with the drug. Thermogravimetric analysis (TGA) was confirmed by thermal stability and degradation pattern of loaded and unloaded hydrogels. The drug-loaded samples presented promising antimicrobial activity against

Indexed as

Antibacterial activityBiocompatibleBiodegradationCytotoxicityDrug deliveryHydrogelsPolymers

Identifiers

PMID38707453
PMCPMC11066320

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.