Evidence map›Paper›PMID 38706964›Full record

ArticleFunction (Oxford, England)2024

Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity.

Sebastian Edman, Oscar Horwath, Thibaux Van der Stede, Sarah Joan Blackwood, Isabel Moberg, Henrik Strömlind, Fabian Nordström, Maria Ekblom, Abram Katz, William Apró and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Function (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sebastian EdmanÅstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.
Oscar HorwathÅstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.
Thibaux Van der StedeDepartment of Movement and Sport Sciences, Ghent University, Ghent 9000, Belgium.
Sarah Joan BlackwoodÅstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.
Isabel MobergÅstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.
Henrik StrömlindÅstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.
Fabian NordströmÅstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.
Maria EkblomDepartment of Physical Activity and Health, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.
Abram KatzÅstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.ORCID 0000-0003-3402-9891
William ApróÅstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.
Marcus MobergÅstrand Laboratory, Department of Physiology, Nutrition and Biomechanics, Swedish School of Sport and Health Sciences, Stockholm 114 33, Sweden.ORCID 0000-0003-3747-0148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise promotes brain plasticity partly by stimulating increases in mature brain-derived neurotrophic factor (mBDNF), but the role of the pro-BDNF isoform in the regulation of BDNF metabolism in humans is unknown. We quantified the expression of pro-BDNF and mBDNF in human skeletal muscle and plasma at rest, after acute exercise (+/- lactate infusion), and after fasting. Pro-BDNF and mBDNF were analyzed with immunoblotting, enzyme-linked immunosorbent assay, immunohistochemistry, and quantitative polymerase chain reaction. Pro-BDNF was consistently and clearly detected in skeletal muscle (40-250 pg mg

Indexed as

Brain-Derived Neurotrophic FactorExerciseMuscle, SkeletalNeuronal PlasticityAdultFemaleHumansLactic AcidMaleProtein PrecursorsYoung AdultBDNF protein, humanBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factor precursorLactic AcidProtein Precursorsexercisefastinglactatemuscle fiber typeneurotrophinsβ-hydroxybutyrate

Identifiers

PMID38706964
PMCPMC11065112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.